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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association analysis of blood-pressure traits in african-ancestry individuals reveals common associated genes in African and Non-African populations
American Journal of Human Genetics, Volume 93, No. 3, Year 2013
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Description
High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 × 10-8) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability. © 2013 The American Society of Human Genetics.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3769920/bin/mmc1.pdf
Authors & Co-Authors
Franceschini, Nora
Unknown Affiliation
Fox, Ervin R.
Unknown Affiliation
Zhang, Zhaogong
Unknown Affiliation
Edwards, Todd L.
Unknown Affiliation
Nalls, Mike A.
Unknown Affiliation
Sung, Yunju
Unknown Affiliation
Tayo, Bamidele O.
Unknown Affiliation
Sun, Yan V.
Unknown Affiliation
Gottesman, Omri
Unknown Affiliation
Adeyemo, Adebowale A.
Unknown Affiliation
Johnson, A. D.
Unknown Affiliation
Young, Jeffery Hunter
Unknown Affiliation
Rice, Kenneth Martin
Unknown Affiliation
Duan, Qing
Unknown Affiliation
Chen, Fang
Unknown Affiliation
Li, Yun
Unknown Affiliation
Tang, Hua
Unknown Affiliation
Fornage, Myriam
Unknown Affiliation
Keene, Keith L.
Unknown Affiliation
Andrews, Jeanette S.
Unknown Affiliation
Smith, Jennifer A.
Unknown Affiliation
Faul, Jessica D.
Unknown Affiliation
Guangfa, Zhang
Unknown Affiliation
Guo, Wei
Unknown Affiliation
Liu, Yu
Unknown Affiliation
Murray, Sarah Shaw
Unknown Affiliation
Musani, Solomon K.
Unknown Affiliation
Srinivasan, Sathanur
Unknown Affiliation
Edwards, Digna R.Velez
Unknown Affiliation
Wang, Heming
Unknown Affiliation
Becker, Lewis C.
Unknown Affiliation
Bovet, Pascal
Unknown Affiliation
Bochud, Murielle
Unknown Affiliation
Broeckel, Ulrich
Unknown Affiliation
Burnier, Michel
Unknown Affiliation
Carty, Cara
Unknown Affiliation
Chasman, Daniel I.
Unknown Affiliation
Ehret, Georg B.
Unknown Affiliation
Chen, Weimin
Unknown Affiliation
Chen, Guanjie
Unknown Affiliation
Chan, Wei
Unknown Affiliation
Ding, Jingzhong
Unknown Affiliation
Dreisbach, Albert W.
Unknown Affiliation
Evans, Michele Kim
Unknown Affiliation
Guo, Xiuqing
Unknown Affiliation
García, Melissa E.
Unknown Affiliation
Jensen, Richard A.
Unknown Affiliation
Keller, Margaux F.
Unknown Affiliation
Lettre, Guillaume
Unknown Affiliation
Lotay, Vaneet S.
Unknown Affiliation
Martin, Lisa W.
Unknown Affiliation
Moore, Jason H.
Unknown Affiliation
Morrison, Alanna C.
Unknown Affiliation
Mosley, Thomas H.
Unknown Affiliation
Ogunniyi, Adesola O.
Unknown Affiliation
Palmas, Walter R.
Unknown Affiliation
Papanicolaou, George John
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Penman, A. D.
Unknown Affiliation
Polak, Joseph F.
Unknown Affiliation
Ridker, Paul M.
Unknown Affiliation
Salako, Babatunde Lawal
Unknown Affiliation
Singleton, Andrew B.
Unknown Affiliation
Shriner, Daniel A.
Unknown Affiliation
Taylor, Kent D.
Unknown Affiliation
Ramachandran, Vasan S.
Unknown Affiliation
Wiggins, Kerri L.
Unknown Affiliation
Williams, Scott M.
Unknown Affiliation
Yanek, Lisa R.
Unknown Affiliation
Zhao, Wei
Unknown Affiliation
Zonderman, Alan B.
Unknown Affiliation
Becker, Diane M.
Unknown Affiliation
Berenson, Gerald
Unknown Affiliation
Boerwinkle, Eric A.
Unknown Affiliation
Böttinger, Erwin P.
Unknown Affiliation
Cushman, Mary E.
Unknown Affiliation
Eaton, Charles B.
Unknown Affiliation
Nyberg, Fredrik
Unknown Affiliation
Heiss, Gerardo M.
Unknown Affiliation
Hirschhron, Joel N.
Unknown Affiliation
Howard, Virginia J.
Unknown Affiliation
Karczewsk, Konrad J.
Unknown Affiliation
Lanktree, Matthew B.
Unknown Affiliation
Kiang, Liu J.
Unknown Affiliation
Liu, Yongmei
Unknown Affiliation
Loos, Ruth J.F.
Unknown Affiliation
Margolis, Karen L.
Unknown Affiliation
Snyder, Michael Paul
Unknown Affiliation
Psaty, Bruce M.
Unknown Affiliation
Schork, Nicholas J.
Unknown Affiliation
Weir, David R.
Unknown Affiliation
Rotimi, Charles N.
Unknown Affiliation
Sale, Michèle M.
Unknown Affiliation
Harris, Tamara B.
Unknown Affiliation
Kardia, Sharon L.R.
Unknown Affiliation
Hunt, Steven C.
Unknown Affiliation
Arnett, Donna K.
Unknown Affiliation
Redline, Susan S.
Unknown Affiliation
Cooper, Richard S.
Unknown Affiliation
Risch, Neil J.
Unknown Affiliation
Rao, Dabeeru C.
Unknown Affiliation
Statistics
Citations: 185
Authors: 100
Affiliations: 56
Identifiers
Doi:
10.1016/j.ajhg.2013.07.010
ISSN:
00029297
e-ISSN:
15376605
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review