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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Tuberculous pericarditis in Tanzanian patients with and without HIV infection
Tubercle and Lung Disease, Volume 75, No. 6, Year 1994
Notification
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Description
Setting: Large academic medical center in Tanzania. Objectives: To determine the etiologies and outcomes of large pericardial effusions in HIV-infected and uninfected patients. Design: Prospective cohort study of patients admitted with new large pericardial effusions, confirmed echocardiographically. Patients had pericardial biopsies and drainage with extensive analysis of tissue and fluid specimens, and were followed with clinical and echocardiographic examinations. Results: Of 28 patients with large pericardial effusions, 19 were infected with HIV-1. 22 had invasive diagnostic procedures: 14 of 14 HIV-infected patients, but only 4 of 8 non-HIV-infected patients, had tuberculous pericarditis (P = 0.01). All but 1 of the HIV-infected patients had strongly positive tuberculin skin tests, and shortterm outcomes were similar in the 2 groups. Conclusion: TB is the predominant cause of large pericardial effusion in HIV-infected patients in this setting; non-HIV-infected patients are more likely to have other etiologies. These patients were at an early stage of HIV infection and responded well to treatment. In settings where microbiological studies are not routinely available, HIV-infected patients with large pericardial effusions may be treated empirically for tuberculosis and monitored for improvement. If improvement does not follow within 2-4 weeks further studies are indicated. HIV-negative patients should undergo diagnostic evaluation initially. © 1994.
Authors & Co-Authors
Cegielski, J. Peter
United States, Durham
Duke University Medical Center
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Lwakatare, J.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Dukes, Carol S.
United States, Durham
Duke University Medical Center
Lema, Leonard E.K.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Lallinger, Gunther J.
United States, Durham
Duke University Medical Center
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Kitinya, James N.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Reller, L. Barth
United States, Durham
Duke University Medical Center
Sheriff, F.
Tanzania, Dar es Salaam
Ebrahim Haji Charitable Health Centre
Statistics
Citations: 65
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/0962-8479(94)90116-3
ISSN:
09628479
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Tanzania