Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis
Liver International, Volume 33, No. 3, Year 2013
Notification
URL copied to clipboard!
Description
Background: Patients with cirrhosis frequently develop renal dysfunction, a proportion of who do not fulfill criteria for hepatorenal syndrome (HRS). We hypothesized that the kidneys in these patients would exhibit histological and biomarker evidence of kidney injury. We looked specifically for TLR expression as they may mediate kidney injury. Methods: Sixty seven subjects (6); alcoholic cirrhosis: compensated (9), acute deterioration of alcoholic cirrhosis (52)] were included. Renal dysfunction was defined as a creatinine of >133 μmol/L and/or according to the AKI network criteria. Urinary biomarkers, KIM-1, πGST, αGST and a novel biomarker, urinary TLR4 were measured. Renal biopsies were also available from eight other alcoholic cirrhosis patients (three non-HRS renal dysfunction; five HRS) that were stained for TLR4 and caspase-3. Results: Fourteen patients developed renal dysfunction, amongst these three had type 2 HRS. KIM-1, πGST and αGST were higher in patients with acute deterioration of cirrhosis compared with patients with compensated cirrhosis, but did not differ between those with and without renal dysfunction. Urinary TLR4 was significantly higher in patients with renal dysfunction associated with infection/inflammation. Kidney biopsies from non-HRS renal dysfunction patients showed tubular damage with evidence of increased tubular expression of TLR4, and caspase-3. Minor changes were observed in HRS patients. Conclusions: The data provide proof of concept that renal dysfunction in patients with cirrhosis with superimposed inflammation is associated with significant tubular injury and apoptosis and with increased renal expression and urinary excretion of the TLR4, suggesting a potential role of TLR4 as mediator of renal injury. © 2012 John Wiley & Sons A/S.
Authors & Co-Authors
Shah, Naina
United Kingdom, London
The Royal Free Hospital
Mohamed, Fatma El Zahraa
United Kingdom, London
The Royal Free Hospital
Egypt, Minya
Minia University
Jover-Cobos, Maria
United Kingdom, London
The Royal Free Hospital
MacNaughtan, Jane
United Kingdom, London
The Royal Free Hospital
Davies, Nathan A.
United Kingdom, London
The Royal Free Hospital
Moreau, Richard
France, Paris
Centre de Recherche Biomédicale Bichat-beaujon
France, Clichy
Hôpital Beaujon
France, Paris
Université Paris Cité
Paradis, Valerie
France, Paris
Centre de Recherche Biomédicale Bichat-beaujon
France, Paris
Université Paris Cité
France, Clichy
Hôpital Beaujon
Moore, Kevin P.
United Kingdom, London
The Royal Free Hospital
Mookerjee, Rajeshwar Prosad
United Kingdom, London
The Royal Free Hospital
Jalan, Rajiv
United Kingdom, London
The Royal Free Hospital
Statistics
Citations: 105
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1111/liv.12047
ISSN:
14783223
e-ISSN:
14783231
Research Areas
Cancer
Violence And Injury