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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nitric oxide and prostaglandin as mediators in the pathogenesis of hyperkinetic circulatory state in a model of endotoxemia-induced portal hypertension
Hepatology International, Volume 7, No. 2, Year 2013
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Description
Aims: To evaluate the participation of nitric oxide (NO) and prostaglandin (PGI2) on hyperdynamic state in endotoxemia-induced portal hypertension (EIP) induced by chronic endotoxemia. Methods: The portal pressure (PP) and mean arterial pressure (MAP) were recorded, in vivo before and after administration of l-NAME (NOS inhibitor) and indomethacin (specific blocker of COX). The vasoactive responses to acetylcholine of thoracic rat aortic rings were studied in vitro before and after nitric oxide and cyclooxygenase blockade using multichannel organ bath. The mRNA expression for isoforms of (cyclooxygenase) COX and nitric oxide synthase (NOS) were analyzed using RT-PCR. Results: Administration of both l-NAME and indomethacin in EIP rabbits significantly reduced (p < 0.05) the PP and reversed the MAP to normal as compared to sham-operated (SO) rabbits. There was impaired vasodilatory response to acetylcholine in EIP rabbits. l-NAME caused a significant reduction in acetylcholine-induced vasorelaxation in SO rabbits than EIP due to preexisting hyperemia in EIP. Indomethacin partially restored vasoresponsiveness to acetylcholine in EIP group. The mRNA expression of eNOS (endothelial NOS) and COX-1 (constitutive COX) were significantly higher in SO than EIP rabbits. iNOS (inducible NOS) and COX-2 (inducible COX) mRNA expression was seen only in EIP rabbits. Conclusions: A significant component of acetylcholine-mediated vasorelaxation in EIP model is modulated by eNOS. There was increased production of contractile prostaglandin in EIP rabbits. iNOS and COX-2 play an important role in the hemodynamic abnormalities of PHT. This novel model of PHT produced by chronic splanchnic endotoxemia in rabbit, mimics impaired vasodilation and vasoreactivity akin to other models of PHT. © 2012 Asian Pacific Association for the Study of the Liver.
Authors & Co-Authors
Rizvi, Moattar Raza
India, New Delhi
G.b. Pant Hospital India
Saudi Arabia, Riyadh
Al-majma'ah University
Tauseef, Mohammad
India, New Delhi
University of Delhi
Shahid, Mohd
India, New Delhi
University of Delhi
Babbar, Rashmi
India, New Delhi
Maulana Azad Medical College
Fahim, Mohammad
India, New Delhi
University of Delhi
Sakhuja, Puja
India, New Delhi
G.b. Pant Hospital India
Sarin, Shiv Kumar
India, New Delhi
G.b. Pant Hospital India
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s12072-012-9397-9
ISSN:
19360533
e-ISSN:
19360541
Research Areas
Noncommunicable Diseases