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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Brucellosis in pregnant women
Clinical Infectious Diseases, Volume 32, No. 8, Year 2001
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Description
Brucella species occasionally cause spontaneous human abortion, but theories regarding whether they do so more frequently than do other infectious pathogens remain controversial. We reviewed 92 pregnant women who presented with acute brucellosis at a Saudi Arabian hospital. From 1983 through 1995, the cumulative incidence of pregnancy and brucellosis was 1.3 cases per 1000 delivered obstetrical discharges. The incidence of spontaneous abortion in the first and second trimesters was 43%, and the incidence of intrauterine fetal death in the third trimester was 2%. Antepartum antimicrobial therapy with cotrimoxazole or cotrimoxazole/rifampin was protective against spontaneous abortion (relative risk, 0.14; 95% confidence interval, 0.06-0.37; P<.0001). The beneficial effect of treatment occurred in women with febrile illness; vaginal bleeding at presentation usually led to spontaneous abortion. This study demonstrated that the incidence of spontaneous abortion among pregnant women with brucellosis is high and that these women should receive prompt therapy with antimicrobial agents when they present for medical care. © 2001 the Infectious Diseases Society of America.
Authors & Co-Authors
Khan, Mohammed Yousuf
Saudi Arabia, Riyadh
King Fahad National Guard Hospital
United States, Phoenix
Maricopa Medical Center
Mah, Manuel W.
Saudi Arabia, Riyadh
King Fahad National Guard Hospital
Canada, Calgary
University of Calgary
Al Memish, Ziad Ahmed
Saudi Arabia, Riyadh
King Fahad National Guard Hospital
Statistics
Citations: 201
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1086/319758
ISSN:
10584838
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female