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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Neutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm)
Journal of Medical Primatology, Volume 28, No. 3, Year 1999
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Description
This study assessed the magnitude and cross-reactivity of the neutralizing antibody response generated by natural SIV infection in wild-caught African green monkeys. Neutralizing antibodies of variable potency, sometimes exceeding a titer of 1:1,000, were detected in 20 of 20 SIV-seropositive African green monkeys in Kenya. Detection of those neutralizing antibodies was dependent on the strain of virus and the cells used for assay, where the most sensitive detection was made with SIVagm1532 in Sup T1 cells. Potent neutralization of SIVagm1532 was seen with contemporaneous autologous serum. Potent neutralization was also detected with laboratory-passaged SIVmac251 and SIVsmB670, but not with SIVsmE660 and two additional strains of SIVagm. Serum samples from rhesus macaques (Macaco mulatta) experimentally infected with either SIVmac251 or SIVsmE660 were capable of low-level neutralization of SIVagm. These results indicate that natural infection with SIV can generate strain-specific neutralizing antibodies in African green monkeys. They also indicate that some neutralization determinants of SIVagm are partially shared with SIV strains that arose in sooty mangabys and were subsequently transmitted to rhesus macaques. © Munksgaard.
Authors & Co-Authors
Gicheru, Michael Muita
Kenya, Nairobi
National Museums of Kenya
Otsyula, Moses G.
Kenya, Nairobi
National Museums of Kenya
Spearman, Paul W.
United States, Nashville
Vanderbilt University Medical Center
Graham, Barney S.
United States, Nashville
Vanderbilt University Medical Center
Miller, Christopher J.
United States, Davis
California National Primate Research Center
Robinson, Harriet Latham
United States, Atlanta
Emory University
Haigwood, Nancy
United States, Seattle
Seattle Biomedical Research Institute
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Statistics
Citations: 24
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1111/j.1600-0684.1999.tb00257.x
ISSN:
00472565
Study Locations
Kenya