Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Shorter androgen receptor CAG repeat lengths associated with cryptorchidism risk among hispanic white boys
Journal of Clinical Endocrinology and Metabolism, Volume 97, No. 3, Year 2012
Notification
URL copied to clipboard!
Description
Context: Cryptorchidism is the most frequent congenital malformation among males, the major established risk factor for testicular germ cell tumors, and a presumed infertility risk factor. Androgens are essential for testicular descent, and functional genetic polymorphisms in the androgen receptor gene (AR) are postulated to influence cryptorchidism risk. Objective: The aim of the study was to investigate whether the CAG repeat length polymorphism in exon 1 of the AR is associated with cryptorchidism risk. Design and Setting: We conducted a family-based genotype-risk association study employing the transmission disequilibrium test for genotypic variants transmitted on the X-chromosome at a university-affiliated regional children's hospital. Participants: We studied 127 Hispanic boys with persistent cryptorchidism and comorbidities described in detail and their biological mothers. Intervention: Genotypes defined by number of CAG repeats were measured for each member of participating son-mother pairs. Main Outcome Measure: Associations between CAG tract length genotype and cryptorchidism risk were estimated using matched-pairs logistic regression. Results: Cryptorchidism risk was significantly associated with shorter CAG repeats [CAG ≤ 19 vs. CAG ≥ 20, odds ratio (OR) = 0.44; 95% confidence interval (CI), 0.23-0.88]. This association was restricted to cryptorchidism with accompanying comorbidities, which was primarily hernia [CAG ≤19 vs. CAG ≥ 20, OR = 0.35 (95% CI, 0.16-0.78)], and was strongest for bilateral cryptorchidism [CAG ≤ 19 vs. CAG ≥ 20, OR = 0.09 (95% CI, 0.010-0.78)]. Conclusions: Androgen receptor genotypes encoding moderate functional variation may influence cryptorchidism risk, particularly among boys with bilateral nondescent or congenital hernia, and may explain in part the elevated risk of testicular seminoma experienced by ex-cryptorchid boys. Mechanistic research is warranted to examine both classical and nonclassical mechanisms through which androgens may influence risk of cryptorchidism and related conditions. Copyright © 2012 by The Endocrine Society.
Authors & Co-Authors
Davis-Dao, Carol A.
United States, Los Angeles
University of Southern California
Koh, Chester J.
United States, Los Angeles
University of Southern California
United States, Los Angeles
Children's Hospital Los Angeles
Pike, Malcolm C.
United States, Los Angeles
University of Southern California
United States, New York
Memorial Sloan-kettering Cancer Center
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Cortessis, Victoria K.
United States, Los Angeles
University of Southern California
Statistics
Citations: 28
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1210/jc.2011-2439
ISSN:
19457197
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Case-Control Study
Participants Gender
Male