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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
Journal of Infectious Diseases, Volume 192, No. 1, Year 2005
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Description
Infection with Mycobacterium tuberculosis in humans results in active disease in ∼10% of immune-competent individuals, with the most-severe clinical manifestations observed when the bacilli infect the central nervous system (CNS). Here, we use a rabbit model of tuberculous meningitis to evaluate the severity of disease caused by the M. tuberculosis clinical isolates CDC1551, a highly immunogenic strain, and HN878 or W4, 2 members of the W/Beijing family of strains. Compared with infection with CDC1551, CNS infection with HN878 or W4 resulted in higher bacillary loads in the cerebrospinal fluid and brain, increased dissemination of bacilli to other organs, persistent levels of tumor necrosis factor-α, higher leukocytosis, and more-severe clinical manifestations. This pathogenic process is associated with the production by HN878 of a polyketide synthase-derived phenolic glycolipid (PGL), as demonstrated by reduced virulence in rabbits infected with an HN878 mutant disrupted in the pks1-15 gene, which is required for PGL synthesis. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Tsenova, Liana
United States, Newark
Public Health Research Institute
Harbacheuski, Ryhor
United States, Newark
Public Health Research Institute
Moreìra, André Luís
United States, New York
Nyu Langone Health
Kurepina, Natalia E.
United States, Newark
Public Health Research Institute
Reed, Michael B.
United States, Bethesda
National Institutes of Health Nih
Mathema, Barun
United States, Newark
Public Health Research Institute
Barry, Clifton Earl
United States, Bethesda
National Institutes of Health Nih
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Statistics
Citations: 202
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1086/430614
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics