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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia
Alzheimer's and Dementia: Translational Research and Clinical Interventions, Volume 3, No. 2, Year 2017
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Description
Introduction Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link. Methods Using the Framingham Study, we examined social relationship measures as predictors of higher serum BDNF level and cumulative incidence of stroke and dementia. Results Among 3294 participants, controlling for age and sex, isolation trended with lower BDNF (odds ratio = 0.69 [0.47–1.00]). Participants with more companionship had reduced risk for stroke (hazard ratio [HR] = 0.59 [0.41–0.83]) and dementia (HR = 0.67 [0.49–0.92]). Greater emotional support was associated with higher BDNF (odds ratio = 1.27 [1.04–1.54]), reduced dementia risk (HR = 0.69 [0.51–0.94], and among smokers, reduced stroke risk (HR = 0.23 [0.10–0.57]). Associations persisted after additional adjustments. BDNF partly mediated the total effect between emotional support and dementia risk. Conclusions Availability of social support appears to be associated with increased BDNF levels and, in certain subsets, reduce risk of subsequent dementia and stroke, thus warranting study of these pathways to understand their role in neuroprotection. © 2017 The Authors
Authors & Co-Authors
Beiser, Alexa S.
United States, Framingham
Framingham Heart Study
United States, Boston
School of Public Health
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Himali, Jayandra Jung
United States, Framingham
Framingham Heart Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Satizabal, Claudia Liliana
United States, Framingham
Framingham Heart Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Aparicio, Hugo J.
United States, Framingham
Framingham Heart Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Weinstein, Galit
United States, Framingham
Framingham Heart Study
Israel, Haifa
University of Haifa
Mateen, Farrah J.
United States, Boston
Harvard Medical School
Berkman, Lisa F.
United States, Boston
Harvard T.h. Chan School of Public Health
Rosand, Jonathan
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Seshadri, Sudha S.
United States, Framingham
Framingham Heart Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Statistics
Citations: 51
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1016/j.trci.2017.03.001
ISSN:
23528737
Research Areas
Environmental
Mental Health
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study