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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
N-terminal prohormone B-type natriuretic peptide and cardiovascular function in Africans and Caucasians: The SAfrEIC study
Heart Lung and Circulation, Volume 21, No. 2, Year 2012
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Description
Background: This study compared NT-proBNP levels and the association with cardiovascular markers between Africans and Caucasians from South Africa. Methods: This cross-sectional study involved 201 Africans and 255 Caucasians from the North West province, South Africa. Serum NT-proBNP concentrations, blood pressure, pulse wave velocity and arterial compliance were measured. Results: NT-proBNP levels were significantly higher (P<0.001) in Africans than Caucasians, also after adjusting for gender, body mass index (BMI) and pulse wave velocity (P=0.008). This significant difference became borderline significant after adjusting for systolic blood pressure (SBP) (P=0.060), and non-significant after adjusting for arterial compliance (P=0.35). In single regression, a significant positive correlation of NT-proBNP with SBP (r=0.26; P<0.001) and pulse pressure (PP) (r=0.28; P<0.001) were shown for Africans only. After multiple adjustments, the associations of NT-proBNP with SBP and PP remained significant in Africans (SBP: β=0.187, P<0.01; PP: β=0.234, P<0.001), with no significant associations in Caucasians. Conclusions: NT-proBNP levels were higher in Africans than Caucasians, independently of BMI and gender. This difference was partly driven by higher SBP and lower arterial compliance in Africans. NT-proBNP was persistently associated with SBP and PP in Africans, but not in Caucasians. These associations may suggest early vascular changes contributing to cardiac alterations in Africans. © 2011.
Authors & Co-Authors
Kruger, Ruan
South Africa, Potchefstroom
North-west University
Schutte, Rudolph
South Africa, Potchefstroom
North-west University
Huisman, Hugo Willem
South Africa, Potchefstroom
North-west University
Hindersson, Peter
Denmark, Hjorring
Sygehus Vendsyssel - Hjørring
Olsen, Michael Hecht
Denmark, Copenhagen
Københavns Universitet
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
Statistics
Citations: 12
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.hlc.2011.10.009
ISSN:
14439506
e-ISSN:
14442892
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
South Africa