Experimental study on the kinetic behavior of moxifloxacin hydrochloride

Moxifloxacin HC1 is a broad spectrum fluoroquinolone antibiotic having strong activity against aerobic and gram positive bacteria. Comparison of drug release profile of different salts of fluoro-quinolones antibiotic moxifloxacin hydrochloride tablets were studied according to the International Con-ference on Harmonization (ICH) guidelines. As per ICH guidelines accelerated stability condition 40 ± 2°C /75% ± 5% RH for 3 months were applied to the samples of different salts of moxifloxacin HCl. After performing all the physical and chemical quality control analysis tests the results showed that they com-plied the official limits provided in official monograph of tablet specifications. HPLC method was used for determination of the assay and percentage purity of the tablets, dissolution testing was performed at disso-lution apparatus for 45 min, buffer solution of 0.1 N HCl at 50 rpm and disintegration was performed by the disintegration assembly. All the physical and chemical tests i.e. friability, hardness, weight variation, color, shape, disintegration time, and dissolution assay were performed. The results showed that all the tests were within the specified official limits and the assay were within the limits of 90-110%; no any drug salt assay was found below the limit of 90% and not exceed any salt above the limit of 110%.