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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The frequency of an IL-18-associated haplotype in Africans
European Journal of Human Genetics, Volume 21, No. 4, Year 2013
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Description
Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk. © 2013 Macmillan Publishers Limited All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3598319/bin/ejhg2012184x1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3598319/bin/ejhg2012184x2.xls
Authors & Co-Authors
Thompson, Simon R.
United Kingdom, London
University College London
Humphries, Steve Eric
United Kingdom, London
University College London
Thomas, Mark G.
Sweden, Uppsala
Evolutionsbiologiskt Centrum
United Kingdom, London
University College London
Ekong, Rosemary M.
United Kingdom, London
University College London
Tarekegn, Ayele
United Kingdom, London
University College London
Ethiopia, Addis Ababa
Center of Human Genetic Diversity
Bekele, Endashaw
Ethiopia, Addis Ababa
Addis Ababa University
Creemer, Olivia J.
United Kingdom, London
University College London
Bradman, Neil N.
United Kingdom, London
University College London
Veeramah, Krishna R.
United States, Tucson
Arizona Research Laboratories
Statistics
Citations: 9
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1038/ejhg.2012.184
ISSN:
10184813
e-ISSN:
14765438
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study