Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
Nature Genetics, Volume 45, No. 7, Year 2013
Notification
URL copied to clipboard!
Description
Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Cortés, Adrián
Australia, Brisbane
The University of Queensland
Hadler, Johanna
Australia, Brisbane
The University of Queensland
Pointon, Jennifer J.
United Kingdom, Birmingham
National Institute for Health Research
Robinson, Philip C.
Australia, Brisbane
The University of Queensland
Karaderi, Tugce
United Kingdom, Birmingham
National Institute for Health Research
Leo, Paul J.
Australia, Brisbane
The University of Queensland
Cremin, Katie
Australia, Brisbane
The University of Queensland
Pryce, Karena
Australia, Brisbane
The University of Queensland
Harris, Jessica A.
Australia, Brisbane
The University of Queensland
Lee, Seunghun
South Korea, Seoul
Hanyang University Hospital for Rheumatic Disease
Joo, Kyung Bin
South Korea, Seoul
Hanyang University Hospital for Rheumatic Disease
Shim, Seung Cheol
South Korea, Daejeon
Eulji University
Weisman, Michael H.
United States, Los Angeles
Cedars-sinai Medical Center
Ward, Michael M.
United States, Bethesda
National Institute of Arthritis and Musculoskeletal and Skin Diseases Niams
Zhou, Xiaodong
United States, Houston
University of Texas Health Science Center at Houston
Garchon, Henri Jean
France, Paris
Institut Cochin
France, Versailles
Université de Versailles Saint-quentin-en-yvelines
Chiocchia, G.
France, Paris
Institut Cochin
Nossent, Johannes
Norway, Tromso
Universitetssykehuset Nord-norge
Australia, Darwin
Royal Darwin Hospital
Lie, Benedicte Alexandra
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Førre,
Norway, Oslo
Oslo Universitetssykehus
Tuomilehto, Jaakko O.I.
Austria, Krems an Der Donau
Donau-universität Krems
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Saudi Arabia, Jeddah
King Abdulaziz University
Laiho, Kari
Finland, Lahti
Paijat-hame Central Hospital
Jiang, Lei
China, Shanghai
Changzheng Hospital
Liu, Yu
China, Shanghai
Changzheng Hospital
Wu, Xin
China, Shanghai
Changzheng Hospital
Bradbury, Linda A.
Australia, Brisbane
The University of Queensland
Elewaut, Dirk
Belgium, Ghent
Universitair Ziekenhuis Gent
Burgos-Vargas, Rubén
Mexico, Mexico
Hospital General de Mexico
Stebbings, Simon M.
New Zealand, Dunedin
Otago Medical School
Appleton, Louise
United Kingdom, Birmingham
National Institute for Health Research
Farrah, Claire
United Kingdom, Birmingham
National Institute for Health Research
Lau, Jonathan
United Kingdom, Birmingham
National Institute for Health Research
Kenna, Tony J.
Australia, Brisbane
The University of Queensland
Haroon, Nigil
Canada, Toronto
Toronto Western Hospital University of Toronto
Ferreira, Manuel A.R.
Australia, Brisbane
Royal Brisbane and Women's Hospital
YANG, Jian
Australia, Brisbane
The University of Queensland
Mulero, Juan
Spain, Majadahonda
Hospital Universitario Puerta de Hierro Majadahonda
Fernández-Sueiro, José Luís
Spain, La Coruna
Instituto de Investigación Biomédica Inibic
González-Gay, Miguel Ángel
Spain, Santander
Fundación Marqués de Valcecilla
Lôpez-Larrea, Carlos
Spain, Oviedo
Asturias Central University Hospital
Spain, Madrid
Fundación Renal Íñigo Álvarez de Toledo Friat
Deloukas, Panos
United Kingdom, Hinxton
Wellcome Sanger Institute
Donnelly, Peter K.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Bowness, Paul
United Kingdom, Birmingham
National Institute for Health Research
Gafney, Karl
United Kingdom, Norwich
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Gaston, John Stanley Hill
United Kingdom, Cambridge
University of Cambridge
Gladman, Dafna D.
Canada, Toronto
University of Toronto
Canada, Toronto
Krembil Research Institute
Canada, Toronto
University Health Network University of Toronto
Rahman, Proton
Canada, St John's
Memorial University of Newfoundland
Maksymowych, Walter P.
Canada, Edmonton
University of Alberta
Xu, Huji
China, Shanghai
Changzheng Hospital
Crusius, Jakob Bart Arie
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van der Horst-Bruinsma, Irene
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Chou, Chung Tei
Taiwan, Taipei
Taipei Veterans General Hospital
Taiwan, Taipei
National Yang-ming University Taiwan
Valle-Oñate, Raphael
Colombia, Chía
Universidad de la Sabana
Romero-Sánchez, Consuelo
Colombia, Chía
Universidad de la Sabana
Hansen, Inger Myrnes
Unknown Affiliation
Pimentel-Santos, Fernando Manuel
Portugal, Lisbon
Nova Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa
Inman, Robert D.
Canada, Toronto
Toronto Western Hospital University of Toronto
Videm, Vibeke
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Norway, Trondheim
Universitetssykehuset I Trondheim
Martin, Javier
Spain, Armilla
Csic - Instituto de Parasitologia y Biomedicina Lopez Neyra Ipbln
Breban, Maxime
France, Paris
Institut Cochin
France, Versailles
Université de Versailles Saint-quentin-en-yvelines
Reveille, John D.
United States, Houston
University of Texas Health Science Center at Houston
Evans, David M.
United Kingdom, London
Medical Research Council
Kim, Tae-hwan
South Korea, Seoul
Hanyang University Hospital for Rheumatic Disease
Wordsworth, Paul B.
United Kingdom, Birmingham
National Institute for Health Research
Brown, Matthew A.
Australia, Brisbane
The University of Queensland
Statistics
Citations: 731
Authors: 65
Affiliations: 46
Identifiers
Doi:
10.1038/ng.2667
ISSN:
10614036
e-ISSN:
15461718
Study Design
Case-Control Study