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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A novel method to identify routes of hepatitis C virus transmission
PLoS ONE, Volume 9, No. 1, Article e86098, Year 2014
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Description
Background: We propose a new approach based on genetic distances among viral strains to infer about risk exposures and location of transmission at population level. Methods: We re-analysed 133 viral sequences obtained during a cross-sectional survey of 4020 subjects living in a hepatitis C virus (HCV) endemic area in 2002. A permutation test was used to analyze the correlation between matrices of genetic distances in the NS5b region of all pairwise combinations of the 133 viral strains and exposure status (jointly exposed or not) to several potential HCV risk factors. Results: Compared to subjects who did not share the same characteristics or iatrogenic exposures, the median Kimura genetic distances of viral strains were significantly smaller between brothers and sisters (0.031 versus 0.102, P<0.001), mother and child (0.044 versus 0.102, P<0.001), father and child (0.045 versus 0.102, P<0.001), or subjects exposed to periodontal treatment (0.084 versus 0.102, P = 0.02). Conversely, viral strains were more divergent between subjects exposed to blood transfusions (0.216 versus 0.102, P = 0.04) or tooth filling or extraction (0.108, versus 0.097, P = 0.05), suggesting acquisition of the virus outside of the village. Conclusion: This method provided insights on where infection took place (household, village) for several sociodemographic characteristics or iatrogenic procedures, information of great relevance for targeting prevention interventions. This method may have interesting applications for virologists and epidemiologists studying transmission networks in health-care facilities or among intravenous drug users. © 2014 Féray et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3900465/bin/pone.0086098.s001.tif
Authors & Co-Authors
Féray, Cyrille
France, Creteil
Hôpital Henri Mondor
Bouscaillou, Julie
France, Paris
Institut Pasteur, Paris
Falissard, Bruno
France, Paris
Troubles du Comportement Alimentaire de L'adolescent
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Arafa, Naglaa A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Bakr, Iman M.A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Hoseiny, Mostafa M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Daly, Maï Mohamed
Egypt, Shibin el Kom
Menoufia University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
A El-Kafrawy, Sherif Aly
Egypt, Shibin el Kom
Menoufia University
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Plancoulaine, Sabine
France, Paris
Inserm
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Minya
Faculty of Medicine
Thiers, Valérie
France, Villejuif
Physiopathologénèse et Traitement Des Maladies du Foie
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
France, Paris
Conservatoire National Des Arts et Metiers
Statistics
Citations: 13
Authors: 13
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0086098
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative