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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The synergy of ChemMatrix Resin® and pseudoproline building blocks renders RANTES, a complex aggregated chemokine
Biopolymers - Peptide Science Section, Volume 84, No. 6, Year 2006
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Description
Traditionally, solid-phase synthesis has relied on polystyrene-based resins for the synthesis of all kinds of peptides. However, due to their high hydrophobicity, these resins have certain limitations, particularly in the synthesis of complex peptides, and in such cases, poly(ethylene glycol) (PEG)-based resins are often found to give superior results. Another powerful strategy for expediting the assembly of complex peptides is to employ pseudoproline dipeptides. These derivatives disrupt the interactions among chains that are usually the cause of poor coupling yields in aggregated sequences. Here we report on an efficient stepwise solid-phase synthesis of RANTES (1-68) by combining the advantages of the totally PEG-based ChemMatrix® resin and pseudoproline dipeptides. © 2006 Wiley Periodicals, Inc.
Authors & Co-Authors
García-Martín, Fayna
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Tulla-Puche, Judit
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Alberício, Fernando
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 52
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1002/bip.20564
ISSN:
10970282