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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: Role of genetic and dietary factors
Clinical Biochemistry, Volume 40, No. 13-14, Year 2007
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Description
Introduction: Total plasma homocysteine (tHcy) is an emerging risk factor for the development of atherosclerosis. However, its relationship with diabetes is still unclear. Objectives: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C → T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. Design and methods: Eighty-six DM patients were compared to 120 healthy volunteers. Results: Associated higher tHcy levels and significantly higher ox-LDL levels (p < 0.001) were found in DM patients compared to healthy subjects. Homozygosity for the T allele of MTHFR was more frequent in diabetics than in healthy subjects (12.8% vs. 7.2%) and it was associated with higher tHcy levels. Moreover, this elevated level was associated with significantly higher ox-LDL levels in DM patients with hypertension (p < 0.05). Improving folate and vitamin C intakes could have beneficial effects on lowering the tHcy and ox-LDL levels. Conclusions: The interplay of genetic and dietary factors modulates the effect of homocysteine on cardiovascular risk factors. © 2007 The Canadian Society of Clinical Chemists.
Authors & Co-Authors
Koubaa, Nadia
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Nakbi, Amel
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Smaoui, Maha
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Abid, N.
Tunisia, Sfax
Chu Hedi-chaker
Châaba, Raja
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Abid, Mohamed Salah
Tunisia, Sfax
Chu Hedi-chaker
Hammami, M. B.
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Statistics
Citations: 47
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.clinbiochem.2007.05.017
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study