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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Polycomb repressive complex 2 contributes to DNA double-strand break repair
Cell Cycle, Volume 12, No. 16, Year 2013
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Description
Polycomb protein histone methyltransferase, enhancer of Zeste homolog 2 (EZH2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. However, it is largely unknown whether EZH2 has a role in modulating the DNA damage response. Here, we show that polycomb repressive complex 2 (PRC2) is recruited to sites of DNA damage. This recruitment is independent of histone 2A variant X (H2AX) and the PI-3-related kinases AT M and DNA-PKcs. We establish that PAR P activity is required for retaining PRC2 at sites of DNA damage. Furthermore, depletion of EZH2 in cells decreases the efficiency of DSB repair and increases sensitivity of cells to gammairradiation. These data unravel a crucial role of PRC2 in determining cancer cellular sensitivity following DNA damage and suggest that therapeutic targeting of EZH2 activity might serve as a strategy for improving conventional chemotherapy in a given malignancy. © 2013 Landes Bioscience.
Authors & Co-Authors
Campbell, Stuart
Canada, Edmonton
University of Alberta
Ismail, Ismail Hassan
Canada, Edmonton
University of Alberta
Egypt, Giza
Faculty of Science
Young, Leah C.
Canada, Edmonton
University of Alberta
Poirier, Guy G.
Canada, Quebec
Chu de Québec-université Laval
Hendzel, Michael J.
Canada, Edmonton
University of Alberta
Statistics
Citations: 110
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.4161/cc.25795
ISSN:
15384101
e-ISSN:
15514005
Research Areas
Cancer
Genetics And Genomics