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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: An observational cohort study
The Lancet, Volume 378, No. 9802, Year 2011
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Description
Loss to follow-up of HIV-positive patients before initiation of antiretroviral therapy can exceed 50 in low-income settings and is a challenge to the scale-up of treatment. We implemented point-of-care counting of CD4 cells in Mozambique and assessed the effect on loss to follow-up before immunological staging and treatment initiation. In this observational cohort study, data for enrolment into HIV management and initiation of antiretroviral therapy were extracted retrospectively from patients' records at four primary health clinics providing HIV treatment and point-of-care CD4 services. Loss to follow-up and the duration of each preparatory step before treatment initiation were measured and compared with baseline data from before the introduction of point-of-care CD4 testing. After the introduction of point-of-care CD4 the proportion of patients lost to follow-up before completion of CD4 staging dropped from 57 (278 of 492) to 21 (92 of 437) (adjusted odds ratio [OR] 0·2, 95 CI 0·15-0·27). Total loss to follow-up before initiation of antiretroviral treatment fell from 64 (314 of 492) to 33 (142 of 437) (OR 0·27, 95 CI 0·21-0·36) and the proportion of enrolled patients initiating antiretroviral therapy increased from 12 (57 of 492) to 22 (94 of 437) (OR 2·05, 95 CI 1·42-2·96). The median time from enrolment to antiretroviral therapy initiation reduced from 48 days to 20 days (p<0·0001), primarily because of a reduction in the median time taken to complete CD4 staging, which decreased from 32 days to 3 days (p<0·0001). Loss to follow-up between staging and antiretroviral therapy initiation did not change significantly (OR 0·84, 95 CI 0·49-1·45). Point-of-care CD4 testing enabled clinics to stage patients rapidly on-site after enrolment, which reduced opportunities for pretreatment loss to follow-up. As a result, more patients were identified as eligible for and initiated antiretroviral treatment. Point-of-care testing might therefore be an effective intervention to reduce pretreatment loss to follow-up. Absolute Return for Kids and UNITAID. © 2011 Elsevier Ltd.
Authors & Co-Authors
Jani, Ilesh Vinodrai
Mozambique, Maputo
Instituto Nacional da Saúde
Sitoe, Nádia E.
Mozambique, Maputo
Instituto Nacional da Saúde
Alfai, Eunice R.
Mozambique, Maputo
Instituto Nacional da Saúde
Chongo, Patrina L.
Mozambique, Maputo
Instituto Nacional da Saúde
Quevedo, Jorge I.
United States, Boston
Clinton Health Access Initiative, Inc.
Rocha, Beatriz M.
United States, Boston
Clinton Health Access Initiative, Inc.
Lehe, Jonathan D.
United States, Boston
Clinton Health Access Initiative, Inc.
Peter, Trevor F.
United States, Boston
Clinton Health Access Initiative, Inc.
Statistics
Citations: 275
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/S0140-6736(11)61052-0
ISSN:
01406736
e-ISSN:
1474547X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Mozambique