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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevention of secondary cases of meningococcal disease in household contacts by vaccination
British Medical Journal, Volume 1, No. 6123, Year 1978
Notification
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Description
Household contacts of patients with group A meningococcal infection were vaccinated with either meningococcal vaccine or tetanus toxoid. Five of the 523 subjects who received tetanus toxoid developed meningococcal meningitis and another four probably had meningococcal disease. Only one possible case of meningococcal infection occurred among 520 contacts vaccinated with meningococcal vaccine. Vaccination had no effect on nasopharyngeal carriage of meningococci. Vaccination of household contacts of patients with group A meningococcal infections is an effective way of using limited supplies of meningococcal vaccine, though its value would be limited in an epidemic. Secondary cases of meningococcal infection often occur within a few days of the index case, and, although vaccine alone seemed to provide adequate prophylaxis in these Nigerian subjects, additional chemoprophylaxis may be needed to cover this critical period. © 1978, British Medical Journal Publishing Group. All rights reserved.
Authors & Co-Authors
Greenwood, Brian M.
Nigeria, Zaria
Ahmadu Bello University
Hassan-King, Musa K.A.
Nigeria, Zaria
Ahmadu Bello University
Whittle, Hilton C.
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 101
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1136/bmj.1.6123.1317
ISSN:
00071447