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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Malaria in patients with sickle cell anemia: Burden, risk factors, and outcome at the outpatient clinic and during hospitalization
Blood, Volume 115, No. 2, Year 2010
Notification
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Description
Approximately 280 000 children are born with sickle cell anemia (SCA) in Africa annually, yet few survive beyond childhood. Falciparum malaria is considered a significant cause of this mortality. We conducted a 5-year prospective surveillance study for malaria parasitemia, clinical malaria, and severe malarial anemia (SMA) in Dar-es-Salaam, Tanzania, between 2004 and 2009.We recorded 10 491 visits to the outpatient clinic among 1808 patients with SCA and 773 visits among 679 patients without SCA. Similarly, we recorded 691 hospital admissions among 497 patients with SCA and 2017 in patients without SCA. Overall, the prevalence of parasitemia was lower in patients with SCA than in patients without SCA both at clinic (0.7% vs 1.6%; OR, 0.53; 95% CI, 0.32-0.86; P = .008) and during hospitalization (3.0% vs 5.6%; OR, 0.46; 95% CI, 0.25-0.94; P = .01). Furthermore, patients with SCA had higher rates of malaria during hospitalization than at clinic, the ORs being 4.29 (95% CI, 2.63-7.01; P < .001) for parasitemia, 17.66 (95% CI, 5.92-52.71; P < .001) for clinical malaria, and 21.11 (95% CI, 8.46-52.67; P < .001) for SMA. Although malaria was rare among patients with SCA, parasitemia during hospitalization was associated with both severe anemia and death. Effective treatment for malaria during severe illness episodes and further studies to determine the role chemoprophylaxis are required. © 2010 by The American Society of Hematology.
Authors & Co-Authors
Makani, Julie B.
Unknown Affiliation
Komba, Albert N.
Unknown Affiliation
Cox, Sharon E.
Unknown Affiliation
Oruo, Julie
Unknown Affiliation
Mwamtemi, Khadija
Unknown Affiliation
Kitundu, Jesse A.
Unknown Affiliation
Magesa, Pius M.
Unknown Affiliation
Rwezaula, Stella
Unknown Affiliation
Meda, Elineema
Unknown Affiliation
Mgaya, Josephine A.
Unknown Affiliation
Pallangyo, Kisali J.
Unknown Affiliation
Okiro, Emelda Aluoch
Unknown Affiliation
Muturi, David
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
Fegan, Greg
Unknown Affiliation
Marsh, Kevin
Unknown Affiliation
Williams, Thomas Neil
Unknown Affiliation
Statistics
Citations: 151
Authors: 17
Affiliations: 8
Identifiers
Doi:
10.1182/blood-2009-07-233528
ISSN:
00064971
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania