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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation
Journal of Virology, Volume 81, No. 11, Year 2007
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Description
Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28- CD62L- CD95+ perforin+ granzyme A+ Bcl-2low). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 months. In contrast, primary infection was accompanied by up-regulation of markers of activation (CD45R0 and HLA-D) on both CMV-specific cells and the overall CD8 T-cell population and division (Ki-67) of specific cells, but neither pattern persisted. At 12 months of age, the CD8 T-cell population of CMV-infected infants was more differentiated than that of uninfected infants. Although the subpopulation of CMV-specific cells remained constant, the CMV peptide-specific gamma interferon response was lower in younger infants and increased with age. As the CD8 T-cell phenotype induced by CMV is indicative of immune dysfunction in the elderly, the existence of a similar phenotype in large numbers of Gambian infants raises the question of whether CMV induces a similarly deleterious effect. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Miles, David J.C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
van der Sande, Marianne A.B.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Jeffries, David J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kaye, Steve
United Kingdom, London
Imperial College London
Ismaïli, Jamila
France, Lille
Institut Pasteur de Lille
Ojuola, Olubukola O.
United States, New York
Bronx-lebanon Hospital Center
Sanneh, Mariama
Gambia, Banjul
Medical Research Council Laboratories Gambia
Touray, Ebrima S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Waight, Pauline A.
United Kingdom, London
Public Health England
Rowland-Jones, Sarah Louise
Gambia, Banjul
Medical Research Council Laboratories Gambia
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Marchant, Arnaud
Belgium, Brussels
Université Libre de Bruxelles
Statistics
Citations: 111
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1128/JVI.00052-07
ISSN:
0022538X
Study Design
Cross Sectional Study