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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The safety and kinetics of intramuscular quinine in Malawian children with moderately severe falciparum malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 84, No. 4, Year 1990
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Description
The safety and kinetics of intramuscular quinine(10 mg salt/kg every 8 h for 3 doses)w ere assessedin Malawian children suffering from uncomplicated falciparum malaria, who were unable to take oral antimalarial drugs. Treatment was completed with oral pyrimethamine-sulfadoxine. The mean (+ SD) peak plasma quinine concentration after the first injection was 9*0 (k2.3) ug/ml, at 1.1 (kO.7) h. Mean plasma concentrations increased further after the second and third doses to a maximum of 115 (f2.6) ug/ml at 16.1 (+3*2) h. No hypotension, hypoglycaemia or electrocardiographic abnormalities developed during quinine treatment. These results provide further evidence for the safety of intramuscular quinine in children with moderately severe malaria. Plasma concentrations of cut-acid glycoprotein (AGP) were higher, and the degree of protein binding of quinine was greater, in acute malaria than in convalescence. There was a significant correlation between AGP concentration and the fraction of plasma quinine bound to plasma protein. These findings suggest a role for AGP in the binding of quinine in plasma in vivo and are of interest since unbound quinine is responsible for both the efficacy and toxicity of the drug. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.
Authors & Co-Authors
Mansor, Sharif Mahsufi
United Kingdom, Liverpool
University of Liverpool
Taylor, Terrie Ellen
United States, East Lansing
Michigan State University
McGrath, C. S.
United Kingdom, Liverpool
University of Liverpool
Edwards, Geoffrey O.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Ward, Stephen Andrew
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Wirima, Jack J.
Malawi, Lilongwe
Kamazu Central Hospital
Molyneux, Malcolm Edward
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 37
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(90)90007-2
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health