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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mycobacterium leprae Specific Antibodies Detected by Radioimmunoassay
Scandinavian Journal of Immunology, Volume 7, No. 2, Year 1978
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Description
A radioimmunoassay was developed for demonstration of antibodies against M. leprae specific antigenic determinants. The specificity of the assay was tested with hyperimmune rabbit antisera against other mycobacteria and shown to be very high. The titre of M. leprae specific antibodies in a lepromatous serum pool was 105. Sixty‐one of sixty‐two lepromatous sera, all of twelve borderline sera and twenty of forty‐eight tuberculoid sera were positive in the assay, whereas all of thirty‐eight control sera from tuberculin positive individuals from a leprosy non‐endemic area were negative. Application as a diagnostic test for subclinical infection with M. leprae is discussed. The principle of the test appears promising for serological distinction between pulmonary infection with M. tuberculosis and other mycobaeteria. Copyright © 1978, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Harboe, Morten H.
Norway, Oslo
Universitetet I Oslo
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Denmark, Copenhagen
Københavns Universitet
Closs, Otto M.
Norway, Oslo
Universitetet I Oslo
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Denmark, Copenhagen
Københavns Universitet
Bjune, Gunnar J.
Norway, Oslo
Universitetet I Oslo
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Denmark, Copenhagen
Københavns Universitet
Kronvall, Giiran
Norway, Oslo
Universitetet I Oslo
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Denmark, Copenhagen
Københavns Universitet
Axelsen, Nils Holger
Norway, Oslo
Universitetet I Oslo
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 53
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3083.1978.tb00433.x
ISSN:
03009475
e-ISSN:
13653083