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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Non-calcified plaque in asymptomatic patients with zero coronary artery calcium score: A systematic review and meta-analysis
Journal of Cardiovascular Computed Tomography, Year 2023
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Description
Background: There is growing interest in understanding the coronary atherosclerotic burden in asymptomatic patients with zero coronary artery calcium score (CACS). In this population, we aimed to investigate the prevalence and severity of non-calcified coronary plaques (NCP) as detected by coronary CT angiography (CCTA), and to analyze the associated clinical predictors. Methods: This was a systematic review with meta-analysis of studies indexed in PubMed/Medline and Web of Science from inception of the database to March 31st, 2023. Using the random-effects model, separate Forest and Galbraith plots were generated for each effect size assessed. Heterogeneity was assessed using the I2 statistics whilst Funnel plots and Egger's test were used to assess for publication bias. Results: From a total of 14 studies comprising 37808 patients, we approximated the pooled summary estimates for the overall prevalence of NCP to be 10% (95%CI: 6%–13%). Similarly, the pooled prevalence of obstructive NCP was estimated at 1.1% (95%CI: 0.7%–1.5%) from a total of 10 studies involving 21531 patients. Hypertension [OR: 1.46 (95%CI:1.31–1.62)] and diabetes mellitus [OR: 1.69 (95%CI: 1.41–1.97)] were significantly associated with developing any NCP, with male gender being the strongest predictor [OR: 3.22 (95%CI: 2.17–4.27)]. Conclusion: There is a low burden of NCP among asymptomatic subjects with zero CACS. In a subset of this population who have clinical predictors of NCP, the addition of CCTA has a potential to provide a better insight about occult coronary atherosclerosis, however, a risk-benefit approach must be factored in prior to CCTA use given the low prevalence of NCP. © 2023
Authors & Co-Authors
Sama, Carlson Babila
United States, Morgantown
West Virginia University School of Medicine Morgantown
Fongwen, Noah T.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Budoff, Matthew J.
United States, Torrance
Harbor-ucla Medical Center
Roberts, Melissa
United States, Morgantown
West Virginia University School of Medicine Morgantown
Balla, Sudarshan
United States, Morgantown
West Virginia University School of Medicine Morgantown
Mills, James D.
United States, Morgantown
West Virginia University School of Medicine Morgantown
Njim, Tsi N.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Greathouse, Mark
United States, Morgantown
West Virginia University School of Medicine Morgantown
Zeb, Irfan
United States, Morgantown
West Virginia University School of Medicine Morgantown
Hamirani, Yasmin S.
United States, Morgantown
West Virginia University School of Medicine Morgantown
Statistics
Citations: 1
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/j.jcct.2023.10.002
ISSN:
19345925
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Systematic review
Participants Gender
Male