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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cardiovascular effects of nose-only water-pipe smoking exposure in mice
American Journal of Physiology - Heart and Circulatory Physiology, Volume 305, No. 5, Year 2013
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Description
Water-pipe smoking (WPS) is a major type of smoking in Middle Eastern countries and is increasing in popularity in Western countries and is perceived as relatively safe. However, data on the adverse cardiovascular effects of WPS are scarce. Here, we assessed the cardiovascular effects of nose-only exposure to mainstream WPS generated by commercially available honey-flavored "moasel" tobacco in BALB/c mice. The duration of the session was 30 min/day for 1 mo. Control mice were exposed to air. WPS caused a significant increase of systolic blood pressure (SBP) in vivo (+13 mmHg) and plasma concentrations of IL-6 (+30%) but not that of TNF-α. Heart concentrations of IL-6 (+184%) and TNF-α (+54%) were significantly increased by WPS. Concentrations of ROS (+95%) and lipid peroxidation (+27%) were significantly increased, whereas those of GSH were decreased (-21%). WPS significantly shortened the thrombotic occlusion time in pial arterioles (-46%) and venules (40%). Plasma von Willebrand factor concentrations were significantly increased (+14%) by WPS. Erythrocyte numbers (+15%) and hematocrit (+17%) were significantly increased. Blood samples taken from mice exposed to WPS and exposed to ADP showed significant platelet aggregation compared with air-exposed mice. WPS caused a significant shortening of activated partial thromboplastin time (-45%) and prothrombin time (-13%). We conclude that 1-mo nose-only exposure to WPS increased SBP and caused cardiac inflammation, oxidative stress, and prothrombotic events. Our findings provide plausible elucidation that WPS is injurious to the cardiovascular system. © 2013 the American Physiological Society.
Authors & Co-Authors
Nemmar, Abderrahim
United Arab Emirates, Al Ain
College of Medicine and Health Sciences United Arab Emirates University
Yuvaraju, Priya Dharshini
United Arab Emirates, Al Ain
College of Medicine and Health Sciences United Arab Emirates University
Beegam, Sumaya
United Arab Emirates, Al Ain
College of Medicine and Health Sciences United Arab Emirates University
John, Annie
United Arab Emirates, Al Ain
College of Medicine and Health Sciences United Arab Emirates University
Raza, H.
United Arab Emirates, Al Ain
College of Medicine and Health Sciences United Arab Emirates University
Ali, B. H. H.
Oman, Muscat
Sultan Qaboos University
Statistics
Citations: 55
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1152/ajpheart.00200.2013
ISSN:
03636135
e-ISSN:
15221539
Research Areas
Environmental
Noncommunicable Diseases
Substance Abuse