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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Severity of anaemia is associated with bone marrow haemozoin in children exposed to Plasmodium falciparum
British Journal of Haematology, Volume 164, No. 6, Year 2014
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Description
There are no large-scale ex vivo studies addressing the contribution of Plasmodium falciparum in the bone marrow to anaemia. The presence of malaria parasites and haemozoin were studied in bone marrows from 290 anaemic children attending a rural hospital in Mozambique. Peripheral blood infections were determined by microscopy and polymerase chain reactions. Bone marrow parasitaemia, haemozoin and dyserythropoiesis were microscopically assessed. Forty-two percent (123/290) of children had parasites in the bone marrow and 49% (111/226) had haemozoin, overlapping with parasitaemia in 83% (92/111) of cases. Sexual and mature asexual parasites were highly prevalent (62% gametocytes, 71% trophozoites, 23% schizonts) suggesting their sequestration in this tissue. Sixteen percent (19/120) of children without peripheral infection had haemozoin in the bone marrow. Haemozoin in the bone marrow was independently associated with decreased Hb concentration (P = 0·005) and was more common in dyserythropoietic bone marrows (P = 0·010). The results of this ex vivo study suggest that haemozoin in the bone marrow has a role in the pathogenesis of malarial-anaemia through ineffective erythropoiesis. This finding may have clinical implications for the development of drugs targeted to prevent and treat malarial-anaemia. © 2014 John Wiley & Sons Ltd.
Authors & Co-Authors
Aguilar, Ruth
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Moraleda, Cinta
Spain, Barcelona
Hospital Clinic Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Achtman, Ariel H.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Australia, Melbourne
University of Melbourne
Mayor, A. G.
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Quintò, Llorenç L.
Spain, Barcelona
Hospital Clinic Barcelona
Cisteró, Pau
Spain, Barcelona
Hospital Clinic Barcelona
Nhabomba, Augusto J.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
MacEte, Eusébio V.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Schofield, Louis
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Australia, Melbourne
University of Melbourne
Alonso, Pedro Luís
Spain, Barcelona
Hospital Clinic Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Menéndez, Clara
Spain, Barcelona
Hospital Clinic Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Statistics
Citations: 38
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1111/bjh.12716
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Mozambique