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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effects of maternal and infant vitamin A supplementation on vitamin A status: A randomised trial in Kenya
British Journal of Nutrition, Volume 98, No. 2, Year 2007
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Description
Postpartum vitamin A supplementation of mothers and infants is recommended, but the efficacy has been questioned. In this double-blind, placebo-controlled trial, Kenyan mother-infant pairs were randomised to maternal vitamin A (400 000 IU) or placebo < 24 h postpartum, and infant vitamin A (100 000 IU) or placebo at 14 weeks. Milk retinol was determined at weeks 4, 14 and 26, and maternal and infant serum retinol at weeks 14 and 26. Infant retinol stores were assessed at week 26, using a modified relative dose response (MRDR) test. Among 564 women, serum retinol at 36 weeks gestation was 0.81 (sd 0.21) μmol/l, and 33.3% were < 0.7 μmol/l. Maternal serum retinol was not different between groups, but milk retinol was higher in the vitamin A group: (0.67 v. 0.60 μmol/l; 0.52 v. 0.44 μmol/l; 0.50 v. 0.44 μmol/l at 4, 14 and 26 weeks, respectively). When expressed per gram fat, milk retinol was higher in the vitamin A group only at 4 weeks. Infant serum retinol was not different between groups. However, although most infants had deficient vitamin A stores (MRDR > 0.06%) at 26 weeks, vitamin A to infants, but not mothers, resulted in a lower proportion of infants with deficient vitamin A stores (69 v. 78%). High-dose postpartum vitamin A supplementation failed to increase serum retinol and infant stores, despite modest effects on milk retinol. Infant supplementation, however, increased stores. There is a need for a better understanding of factors affecting absorption and metabolism of vitamin A. © The Authors 2007.
Authors & Co-Authors
Ayah, Rosemary
Unknown Affiliation
Mwaniki, David Lemmy
Unknown Affiliation
Magnussen, Pascal
Unknown Affiliation
Tedstone, Alison E.
Unknown Affiliation
Marshall, Thomas Fde C.
Unknown Affiliation
Alusala, Dorcas N.
Unknown Affiliation
Luoba, Alfred I.
Unknown Affiliation
Kaestel, Pernille
Unknown Affiliation
Michaelsen, Kim Fleischer
Unknown Affiliation
Friis, Henrik M.U.
Unknown Affiliation
Statistics
Citations: 43
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1017/S0007114507705019
ISSN:
00071145
e-ISSN:
14752662
Research Areas
Disability
Maternal And Child Health
Study Locations
Kenya
Participants Gender
Female