Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CORRELATION OF PLASMA AND BRAIN AMINO ACID AND PUTATIVE NEUROTRANSMITTER ALTERATIONS DURING ACUTE HEPATIC COMA IN THE RAT
Journal of Neurochemistry, Volume 32, No. 2, Year 1979
Notification
URL copied to clipboard!
Description
During acute hepatic coma following two‐stage hepatic devascularization in the rat, profound changes occurred in plasma and whole‐brain amino acids and putative neurotransmitters. Brain ammonia, glutamine and GABA were increased, aspartate was decreased, while glutamate was unchanged. An increase in brain tryptophan was accompanied by a similar increase in plasma unbound tryptophan but decreased plasma total tryptophan. These changes occurred in the presence of high plasma levels of the other neutral amino acids, including the branched chain amino acids. Plasma insulin was unchanged while glucagon levels rose, resulting in a decreased insulin to glucagon ratio. These results suggest that while plasma unbound tryptophan may influence brain tryptophan levels, altered plasma concentrations of neutral amino acids which compete with tryptophan for transport into the brain do not contribute to the increase in brain tryptophan observed during acute hepatic coma. Copyright © 1979, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Mans, A. M.
South Africa, Cape Town
Faculty of Health Sciences
Saunders, Stuart John
South Africa, Cape Town
Faculty of Health Sciences
Kirsch, Ralph Emmanuel
South Africa, Cape Town
Faculty of Health Sciences
Biebuyck, Julien F.
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 101
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1111/j.1471-4159.1979.tb00350.x
ISSN:
00223042
e-ISSN:
14714159