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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Is a patient's self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975
Annals of Oncology, Volume 17, No. 11, Year 2006
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Description
Background: The aim of this prognostic factor analysis was to investigate if a patient's self-reported health-related quality of life (HRQOL) provided independent prognostic information for survival in non-small cell lung cancer (NSCLC) patients. Patients and methods: Pretreatment HRQOL was measured in 391 advanced NSCLC patients using the EORTC QLQ-C30 and the EORTC Lung Cancer module (QLQ-LC13). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap validation technique was used to assess the stability of the outcomes. Results: The final multivariate Cox regression model retained four parameters as independent prognostic factors for survival: male gender with a hazard ratio (HR) = 1.32 (95% CI 1.03-1.69; P = 0.03); performance status (0 to 1 versus 2) with HR = 1.63 (95% CI 1.04-2.54; P = 0.032); patient's self-reported score of pain with HR= 1.11 (95% CI 1.07-1.16; P < 0.001) and dysphagia with HR = 1.12 (95% CI 1.04-1.21; P = 0.003). A 10-point shift worse in the scale measuring pain and dysphagia translated into an 11% and 12% increased in the likelihood of death respectively. A risk group categorization was also developed. Conclusion: The results suggest that patients' self-reported HRQOL provide independent prognostic information for survival. This finding supports the collection of such data in routine clinical practice. © 2006 Oxford University Press.
Authors & Co-Authors
Efficace, Fabio
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Bottomley, Andrew
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Smit, Egbert F.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Lianes, Pilar
Spain, Barcelona
Hospital de Mataro
Legrand, Catherine L.
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Debruyne, Channa
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Schramel, Fránz M.N.H.
Netherlands, Nieuwegein
St. Antonius Ziekenhuis
Smit, Hans J.M.
Netherlands, Arnhem
Rijnstate Hospital
Gaafar, Rabab Mohamed
Egypt, Giza
National Cancer Institute
Biesma, Bonne
Netherlands, 's-hertogenbosch
Jeroen Bosch Hospital
Manegold, Christian
Germany, Mannheim
Universitätsklinikum Mannheim
Coens, Corneel
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Giaccone, Giuseppe
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van Meerbeeck, J. P.A.M.
Belgium, Ghent
Universitair Ziekenhuis Gent
Statistics
Citations: 174
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1093/annonc/mdl183
ISSN:
09237534
e-ISSN:
15698041
Research Areas
Cancer
Disability
Environmental
Health System And Policy
Participants Gender
Male