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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): Randomised placebo-controlled trial
The Lancet, Volume 364, No. 9442, Year 2004
Notification
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Description
Background Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial—a multicentre international collaboration—aimed to confirm or refute such an effect by recruiting 20 000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation. Analysis was by intention to treat. Effects on outcomes within 2 weeks of randomisation are presented in this report. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN74459797. Findings Compared with placebo, the risk of death from all causes within 2 weeks was higher in the group allocated corticosteroids (1052 [21·1%] vs 893 [17·9%] deaths; relative risk 1·18 [95% CI 1·09-1·27]; p=0·0001). The relative increase in deaths due to corticosteroids did not differ by injury severity (p=0·22) or time since injury (p=0·05). Interpretation Our results show there is no reduction in mortality with methylprednisolone in the 2 weeks after head injury. The cause of the rise in risk of death within 2 weeks is unclear. © 2004, Lancet Publishing Group. All rights reserved.
Authors & Co-Authors
Olldashi, Fatos
Unknown Affiliation
Lede, Roberto L.
Unknown Affiliation
Piñero, Gustavo Rene
Unknown Affiliation
Videtta, Walter
Unknown Affiliation
Svampa, Silvana
Unknown Affiliation
Tallott, Mandy
Australia, Southport
Gold Coast Hospital
Mazairac, Guy
Belgium, Namur
Centre Hospitalier Régional de Namur
Braet, Veronique
Unknown Affiliation
Jacques, Jean Marie
Belgium, La Louvière
Hospital of Jolimont
Gualteros, Wilson
Colombia
Hospital Universitario San Jorge
Arango, Miguel Fernando
Colombia, Medellin
Clínica Las Américas
Ciro, Juan Diego
Colombia, Medellin
Clínica Las Américas
Gómez, Carolina
Colombia, Medellin
Hospital General de Medellin Luz Castro de Gutiérrez - E.s.e
Pastrana, Irene
Cuba
Hospital Abel Santamaría Cuadrado
Svoboda, Petr
Unknown Affiliation
Kantorová, Ilona
Unknown Affiliation
Ochmann, Jiří
Unknown Affiliation
Scheer, Peter
Unknown Affiliation
Edelmann, Karel
Unknown Affiliation
Pachl, Jan
Unknown Affiliation
Bürger, Jan
Czech Republic, Pribram
Hospital Pribram
Kramář, Filip
Czech Republic, Prague
Charles University
Ecuador, Guayaquil
Hospital Luis Vernaza
Daccach, Alberto
Czech Republic, Prague
Charles University
Ecuador, Guayaquil
Hospital Luis Vernaza
Ortega, Antonio
Czech Republic, Prague
Charles University
Ecuador, Guayaquil
Hospital Luis Vernaza
Khamis, Hussein
Egypt, Cairo
Mataria Teaching Hospital
El-Sayed, Hesham Fathey
Egypt, Ismailia
Suez Canal University
Khalil, Nabil H.
Egypt, Ismailia
Suez Canal University
Negm, Nader E.
Egypt, Ismailia
Suez Canal University
Kleist, Waltraud
Germany, Greifswald
Universität Greifswald
Andrews, Nii B.
Ghana, Gha
Narh-bita Hospital
Nakos, George
Greece, Ioannina
University General Hospital of Ioannina
Myrianthefs, Pavlos M.
Greece, Athens
Kat Hospital
Ravi, Ramalingam R.
Unknown Affiliation
Dewan, Yashbir
India, Ludhiana
Christian Medical College & Hospital, Ludhiana
Gupta, Sunil Kumar
India, Chandigarh
Postgraduate Institute of Medical Education & Research, Chandigarh
Panikar, Dilip
India, Kochi
Amrita Institute of Medical Sciences India
Plunkett, Patrick K.
Unknown Affiliation
Qureshi, Mahmood M.
Kenya, Kisumu
Aga Khan Hospital
Jafri Malin, Abdullah Malin
Malaysia, Kota Bharu
Hospital Universiti Sains Malaysia
Ghani, Abdul Rahman Izaini
Malaysia, Kota Bharu
Hospital Universiti Sains Malaysia
Hutchinson, Robyn
New Zealand, Dunedin
Dunedin Hospital
Komolafe, Edward Oluwole
Nigeria, Ife
Obafemi Awolowo University
Adeolu, Augustine Abiodun
Nigeria, Ife
Obafemi Awolowo University
Komolafe, Morenikeji Adeyoyin
Nigeria, Ife
Obafemi Awolowo University
Shehu, Bello Bala
Nigeria, Sokoto
Usmanu Danfodiyo University
Odebode, Olugbenga Timothy
Nigeria, Ilorin
University of Ilorin
Oluwadiya, Kehinde Sunday
Nigeria, Osogbo
Lautech Teaching Hospital
Jooma, Rashid A.
Unknown Affiliation
Balica, Laura
Unknown Affiliation
El-Dawlatly, Abdelazeem Ali
Saudi Arabia, Riyadh
King Khalid University Hospital
Alwatidy, Sherif
Saudi Arabia, Riyadh
King Khalid University Hospital
Tan, James Siah Heng
Singapore, Singapore City
National Neuroscience Institute of Singapore
Trenkler, Štefan
Unknown Affiliation
Hartzenberg, Bennie H.
South Africa, Tygerberg
Tygerberg Hospital
Nathoo, Narendra
South Africa, Durban
Wentworth Hospital
Khumalo, Sipho
South Africa, Durban
Wentworth Hospital
Tracey, Ralph
Unknown Affiliation
Múñoz-Sánchez, María Ángeles
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Murillo-Cabezas, Francisco
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Flores-Cordero, Juan Manuel
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Laloë, Véronique
Switzerland, Geneva
Medecins Sans Frontieres
Mandrella, Bernhard
Switzerland, Geneva
Medecins Sans Frontieres
Perera, Sunil D.
Sri Lanka, Colombo
National Hospital of Sri Lanka
Stocker, Reto A.
Switzerland, Zurich
Universitatsspital Zurich
Ludwig, Silke
Switzerland, Zurich
Universitatsspital Zurich
Zimmermann, Heinz
Switzerland, Bern
University Hospital Bern
Jerbi, Zouheir
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Habib Thameur
Borsali-Falfoul, Nébiha
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Habib Thameur
Rezgui, Monia
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Habib Thameur
Çakar, Nahit
Turkey, Istanbul
İstanbul Tıp Fakültesi
Ssenyonjo, Hussein
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Kobusingye, Olive Chifefe
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Yates, David W.
United Kingdom, Salford
Salford Royal Hospital
Lecky, Fiona Elizabeth
United Kingdom, Salford
Salford Royal Hospital
Bleetman, Anthony
United Kingdom, Birmingham
Heartlands Hospital
Pantrini, Shiela A.
United Kingdom, Birmingham
Heartlands Hospital
Roberts, Trudy
United Kingdom, Manchester
North Manchester General Hospital
Pinto, Alan
United Kingdom, Wigan
Royal Albert Edward Infirmary
Lee, Diane
United Kingdom, Wigan
Royal Albert Edward Infirmary
Brayley, Nigel F.
United Kingdom, Colchester
Colchester Hospital
Graham, Sarah
United Kingdom, Prescot
Whiston Hospital
Green, Marcus
United Kingdom, Birmingham
Selly Oak Hospital
Fogg, Barbara
United Kingdom, Bolton
Royal Bolton Hospital
Cottingham, Rowland L.
United Kingdom, Eastbourne
Eastbourne District General Hospital
United Kingdom, Brighton
Royal Sussex County Hospital
Funnell, Sam
United Kingdom, Eastbourne
Eastbourne District General Hospital
Summers, Claire
United Kingdom, Manchester
Trafford General Hospital
Morrice, Amanda
United Kingdom, Gillingham
Medway Maritime Hospital
Shaw, Anita
United Kingdom, Barrow-in-furness
Furness General Hospital
Luthra, Pramod
United Kingdom, Oldham
The Royal Oldham Hospital
Dixon, Gill
United Kingdom, Oldham
The Royal Oldham Hospital
Butler, John M.
United Kingdom, Stockport
Stepping Hill Hospital
Young, Mike
United Kingdom, Stockport
Stepping Hill Hospital
Mason, Sue
United Kingdom, Derby
Northern General Hospital
Loveday, Ian
United Kingdom, Derby
Northern General Hospital
Clark, Christine
United Kingdom, Blackburn
Royal Blackburn Teaching Hospital
Wilson, Paul
United Kingdom, Cheltenham
Cheltenham General Hospital
Perez, Rosa
United Kingdom, Kent
Queen Elizabeth the Queen Mother Hospital
Eljamel, Sam
United Kingdom, Dundee
University of Dundee School of Medicine
Wasserberg, Jonathan
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Shale, Helen
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Pennell, Aaron
United Kingdom, Harlow
The Princess Alexandra Hospital
Jaffey, Lawrence
United Kingdom, Liverpool
Royal Liverpool University Hospital
Graves, Michael
United Kingdom, Liverpool
Royal Liverpool University Hospital
Richardson, Jeremy
United Kingdom, Aberdeen
Aberdeen Royal Infirmary
Gallagher, Claire
United Kingdom, Aberdeen
Aberdeen Royal Infirmary
Pennycook, Alan G.
United Kingdom, Wirral
Arrowe Park Hospital
Chikhani, Claude
United Kingdom, Doncaster
Doncaster Royal Infirmary
Zoltie, Nigel
United Kingdom, Leeds
Leeds General Infirmary
Stell, Ian M.
United Kingdom, Orpington
Bromley Hospitals Nhs Trust
Hulse, William
United Kingdom, Harrogate
Harrogate District Hospital
Crossley, Jacqueline
United Kingdom, Harrogate
Harrogate District Hospital
Watkins, Laurence Dale
United Kingdom, London
Ucl Queen Square Institute of Neurology
Dorani, Balu J.
United Kingdom, Tyne and Wear
Queen Elizabeth Hospital, Gateshead
Baigent, Colin
Unknown Affiliation
Chadwick, David Robert
Unknown Affiliation
Duley, Lelia M.M.
Unknown Affiliation
Farrell, Barbara
Unknown Affiliation
Peto, Richard R.
Unknown Affiliation
Roberts, Ian G.
Unknown Affiliation
Sandercock, Peter A.G.
Unknown Affiliation
Teasdale, Graham Michael T.
Unknown Affiliation
Macmahon, Stephen W.
Unknown Affiliation
Warlow, Charles P.
Unknown Affiliation
Edwards, Phil James
Unknown Affiliation
Shakur-Still, Haleema
Unknown Affiliation
Ramos, Maria
Unknown Affiliation
Free, Caroline Jane
Unknown Affiliation
Statistics
Citations: 822
Authors: 127
Affiliations: 130
Identifiers
Doi:
10.1016/S0140-6736(04)17188-2
ISSN:
01406736
Research Areas
Disability
Violence And Injury
Study Design
Randomised Control Trial
Study Approach
Systematic review