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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2
European Journal of Medicinal Chemistry, Volume 46, No. 9, Year 2011
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Description
A range of 6-substituted imidazo[1,2-a]pyridines were synthesized using a multicomponent coupling reaction. Most of these compounds were found to exhibit excellent activity against the colon cancer cell lines HT-29 and Caco-2, whilst not showing significant toxicity against white blood cells. Our studies have shown that the proteolytic phase of apoptosis was initiated 2 h after treatment with these imidazo-[1,2-a]pyridines. The data suggests that the imidazo[1,2-a]pyridine-induced cell death in HT-29 and Caco-2 cells is mediated via pathway(s) that include the release of cytochrome c from the mitochondria to the cytosol and the activation of caspase 3 and caspase 8. © 2011 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Dahan-Farkas, Nurit
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Langley, Candice
South Africa, Johannesburg
University of the Witwatersrand
Rousseau, Amanda
South Africa, Johannesburg
University of the Witwatersrand
Yadav, Dharmendra B.
South Africa, Johannesburg
University of the Witwatersrand
Davids, Hajierah
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Gqeberha
Nelson Mandela University
de Koning, Charles Bernard D.E.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 79
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejmech.2011.07.036
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer