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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Early- versus late-onset obsessive-compulsive disorder: Investigating genetic and clinical correlates
Psychiatry Research, Volume 128, No. 2, Year 2004
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Description
There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD appears to be a subtype that exhibits distinct clinical features and that is associated with greater familial loading. In the present investigation, South African OCD patients (n=252) were stratified according to age of onset and were clinically assessed. Additionally, selected variants in genes encoding serotonergic and dopaminergic components were investigated in a Caucasian OCD subset (n=180). This subgroup was further stratified to evaluate the role that these candidate genes may play in the genetically homogeneous Afrikaner subset (n=80). Analysis of the clinical data revealed an association between early age of onset and an increased frequency of tics, Tourette's disorder, and trichotillomania (TTM). The genetic studies yielded statistically significant results when the allelic distributions of genetic variants in the dopamine receptor type 4 gene (DRD4) were analysed in the Caucasian OCD cohort. These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Joanna Hemmings, Sîan Megan
South Africa, Stellenbosch
Stellenbosch University
South Africa, Observatory
Faculty of Health Sciences
Kinnear, Craig J.
South Africa, Stellenbosch
Stellenbosch University
Lochner, Christine
South Africa, Stellenbosch
Stellenbosch University
Niehaus, Dana J.H.
South Africa, Stellenbosch
Stellenbosch University
Knowles, James A.
United States, New York
Columbia University
Moolman-Smook, Johanna Catharina
South Africa, Stellenbosch
Stellenbosch University
Corfield, Valérie Ann
South Africa, Stellenbosch
Stellenbosch University
Stein, Dan J.
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 102
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.psychres.2004.05.007
ISSN:
01651781
Research Areas
Genetics And Genomics
Study Design
Cohort Study