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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Combined spatial prediction of schistosomiasis and soil-transmitted helminthiasis in sierra leone: A tool for integrated disease control
PLoS Neglected Tropical Diseases, Volume 6, No. 6, Article e1694, Year 2012
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Description
Background: A national mapping of Schistosoma haematobium was conducted in Sierra Leone before the mass drug administration (MDA) with praziquantel. Together with the separate mapping of S. mansoni and soil-transmitted helminths, the national control programme was able to plan the MDA strategies according to the World Health Organization guidelines for preventive chemotherapy for these diseases. Methodology/Principal Findings: A total of 52 sites/schools were selected according to prior knowledge of S. haematobium endemicity taking into account a good spatial coverage within each district, and a total of 2293 children aged 9-14 years were examined. Spatial analysis showed that S. haematobium is heterogeneously distributed in the country with significant spatial clustering in the central and eastern regions of the country, most prevalent in Bo (24.6% and 8.79 eggs/10 ml), Koinadugu (20.4% and 3.53 eggs/10 ml) and Kono (25.3% and 7.91 eggs/10 ml) districts. By combining this map with the previously reported maps on intestinal schistosomiasis using a simple probabilistic model, the combined schistosomiasis prevalence map highlights the presence of high-risk communities in an extensive area in the northeastern half of the country. By further combining the hookworm prevalence map, the at-risk population of school-age children requiring integrated schistosomiasis/soil-transmitted helminth treatment regimens according to the coendemicity was estimated. Conclusions/Significance: The first comprehensive national mapping of urogenital schistosomiasis in Sierra Leone was conducted. Using a new method for calculating the combined prevalence of schistosomiasis using estimates from two separate surveys, we provided a robust coendemicity mapping for overall urogenital and intestinal schistosomiasis. We also produced a coendemicity map of schistosomiasis and hookworm. These coendemicity maps can be used to guide the decision making for MDA strategies in combination with the local knowledge and programme needs. © 2012 Hodges et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3378624/bin/pntd.0001694.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3378624/bin/pntd.0001694.s002.doc
Authors & Co-Authors
Hodges, Mary Hamer
United States, New York
Helen Keller International
Soares Magalhães, Ricardo J.
Australia, Brisbane
The University of Queensland
Paye, Jusufu
United States, New York
Helen Keller International
Koroma, Joseph Brima
Sierra Leone, Freetown
Ministry of Health and Sanitation
Sonnie, Mustapha
United States, New York
Helen Keller International
Clements, Archie C.A.
Australia, Brisbane
The University of Queensland
Zhang, Yaobi
Senegal, Dakar
Who Regional Office for Africa
Statistics
Citations: 32
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0001694
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Sierra Leone