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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
Proceedings of the National Academy of Sciences of the United States of America, Volume 102, No. 13, Year 2005
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Description
Malaria is a major global health problem for which an effective vaccine is required urgently. Prime-boost vaccination regimes involving plasmid DMA and recombinant modified vaccinia virus Ankara-encoding liver-stage malaria antigens have been shown to be powerfully immunogenic for T cells and capable of inducing partial protection against experimental malaria challenge in humans, manifested as a delay in time to patent parasitemia. Here, we report that substitution of plasmid DMA as the priming vector with a specific attenuated recombinant fowlpox virus, FP9, vaccine in such prime-boost regimes can elicit complete sterile protection that can last for 20 months. Protection at 20 months was associated with persisting memory but not effector T cell responses. The protective efficacy of various immunization regimes correlated with the magnitude of induced immune responses, supporting the strategy of maximizing durable T cell immunogenicity to develop more effective liver-stage vaccines against Plasmodium falciparum malaria. © 2005 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC555695/bin/pnas_102_13_4836__.html
Authors & Co-Authors
Webster, Daniel Peter
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Dunachie, Susanna J.
United Kingdom, Oxford
Churchill Hospital
Vuola, Jenni M.
United Kingdom, Oxford
Churchill Hospital
Berthoud, Tamara Katherine
United Kingdom, Oxford
Churchill Hospital
Keating, Sheila Marie
United Kingdom, Oxford
Churchill Hospital
Laidlaw, Stephen M.
United Kingdom, Surrey
The Pirbright Institute
McConkey, Samuel J.
United Kingdom, Oxford
Churchill Hospital
Poulton, Ian D.
United Kingdom, Oxford
Churchill Hospital
Andrews, Laura
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Andersen, Rikke Fredslund
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Bejon, Philip A.
United Kingdom, Oxford
Churchill Hospital
Butcher, Geoffrey A.
United Kingdom, London
Imperial College London
Sinden, Robert E.
United Kingdom, London
Imperial College London
Skinner, Michael A.
United Kingdom, Surrey
The Pirbright Institute
Gilbert, Sarah C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hill, Adrian V. S.
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 221
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1073/pnas.0406381102
ISSN:
00278424
Research Areas
Infectious Diseases
Maternal And Child Health