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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Patterns of transmitted HIV drug resistance in Europe vary by risk group
PLoS ONE, Volume 9, No. 4, Article e94495, Year 2014
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Description
Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p<0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs. © 2014 Frentz et al.
Authors & Co-Authors
Van De Vijver, D. A.M.C.
Netherlands, Rotterdam
Erasmus Mc
Abecasis, A. Barroso
Portugal, Lisbon
Universidade Nova de Lisboa
Albert, Jan
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Hamouda, Osamah
Germany, Berlin
Robert Koch Institute
Jörgensen, Louise Bruun
Denmark, Copenhagen
Statens Serum Institut
Kücherer, Claudia
Germany, Berlin
Robert Koch Institute
Struck, Daniel
Luxembourg, Strassen
Luxembourg Institute of Health
Schmit, Jean Claude
Luxembourg, Strassen
Luxembourg Institute of Health
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Vercauteren, Jurgen
Belgium, Leuven
Ku Leuven
Åsjö, Birgitta
Norway, Bergen
Gade Institute
Balotta, Claudia
Italy, Milan
Università Degli Studi Di Milano
Bergin, Colm J.
Ireland, Dublin
St James's Hospital
Beshkov, Danail
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Camacho, Ricardo Jorge
Portugal, Lisbon
Universidade Nova de Lisboa
Portugal, Lisbon
Centro Hospitalar de Lisboa Ocidental
Clotet, Bonaventura
Spain, Badalona
Hospital Universitari Germans Trias I Pujol
Grossman, Zehava
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Horban, Andrzéj
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Korn, Klaus
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Kostrikis, Leontios G.
Cyprus, Nicosia
University of Cyprus
Nielsen, Claus M.
Germany, Berlin
Robert Koch Institute
Oţelea, Dan
Unknown Affiliation
Paraskevis, D. N.
Greece, Athens
School of Medicine
Paredes, Roger
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Poljak, Mario
Slovenia, Ljubljana
Univerza V Ljubljani
Puchhammer-Stöckl, Elisabeth
Austria, Vienna
Medizinische Universität Wien
Sönnerborg, Anders B.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Stockholm
Karolinska Institutet
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
Vandamme, Anne Mieke
Belgium, Leuven
Ku Leuven
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 32
Authors: 30
Affiliations: 29
Identifiers
Doi:
10.1371/journal.pone.0094495
ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Participants Gender
Male