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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Frequent Transient Hepatitis C viremia without Seroconversion among Healthcare Workers in Cairo, Egypt
PLoS ONE, Volume 8, No. 2, Article e57835, Year 2013
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Description
Backgrounds: With 10% of the general population aged 15-59 years chronically infected with hepatitis C virus (HCV), Egypt is the country with the highest HCV prevalence worldwide. Healthcare workers (HCWs) are therefore at particularly high risk of HCV infection. Our aim was to study HCV infection risk after occupational blood exposure among HCWs in Cairo. Methodology/Principal Findings: The study was conducted in 2008-2010 at Ain Shams University Hospital, Cairo. HCWs reporting an occupational blood exposure at screening, having neither anti-HCV antibodies (anti-HCV) nor HCV RNA, and exposed to a HCV RNA positive patient, were enrolled in a 6-month prospective cohort with follow-up visits at weeks 2, 4, 8, 12 and 24. During follow-up, anti-HCV, HCV RNA and ALT were tested. Among 597 HCWs who reported a blood exposure, anti-HCV prevalence at screening was 7.2%, not different from that of the general population of Cairo after age-standardization (11.6% and 10.4% respectively, p = 0.62). The proportion of HCV viremia among index patients was 37%. Of 73 HCWs exposed to HCV RNA from index patients, nine (12.3%; 95%CI, 5.8-22.1%) presented transient viremia, the majority of which occurred within the first two weeks after exposure. None of the workers presented seroconversion or elevation of ALT. Conclusions/Significance: HCWs of a general University hospital in Cairo were exposed to a highly viremic patient population. They experienced frequent occupational blood exposures, particularly in early stages of training. These exposures resulted in transient viremic episodes without established infection. These findings call for further investigation of potential immune protection against HCV persistence in this high risk group. © 2013 Munier et al.
Authors & Co-Authors
Munier, Aline
France, Paris
Institut Pasteur, Paris
Marzouk, D.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Abravanel, Florence
France, Paris
Inserm
France, Toulouse
Hôpital Purpan
El-Daly, Maï Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Shibin el Kom
Menoufia University
Taylor, Sylvia M.
France, Paris
Institut Pasteur, Paris
Mamdouh, Rasha
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Salah-Eldin, Waleed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Arab, Hanan Ezz
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Sos, Dalia Gaber
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Momen, Mohamed Abdel Maguid Tolba
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Okasha, Omar
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Le-Fouler, Lénaïg
France, Paris
Institut Pasteur, Paris
El-Hosini, Mostafa
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Izopet, Jacques
France, Paris
Inserm
France, Toulouse
Hôpital Purpan
Rafik, Mona M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Albert, Matthew L.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Menia
Minia Faculty of Medicine
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Delarocque-Astagneau, Elisabeth
France, Paris
Institut Pasteur, Paris
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
France, Paris
Conservatoire National Des Arts et Metiers
Statistics
Citations: 20
Authors: 20
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0057835
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Egypt