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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Clinical evaluation of 451 patients with HIV related non-hodgkin's lymphoma: Experience of the italian cooperative group on AIDS and tumors (GICAT)
Leukemia and Lymphoma, Volume 20, No. 1-2, Year 1995
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Description
We report the clinical experience in 451 patients with HIV related non-Hodgkin's lymphoma (HIV-NHL) observed within the Italian Cooperative Group on AIDS and Tumors (GICAT: Gruppo Italiano Cooperativo AIDS e Tumori), a significant number of them being treated at the Aviano Cancer Center (ACC). High grade histology according to the Working Formulation, stages III-IV and B symptoms were detected in the majority of patients. The median survival was 6 months. Based on the Cox model, three factors appeared to influence survival: advanced stage, treatment received and failure to obtain complete remission (CR). In another study aimed at comparing between chemotherapy with or without G-CSF it was shown that G-CSF significantly reduced white blood cells (WBC) nadir duration, the mean delays between cycles, the mean hospitalization time for toxicity per patient treated, without increasing significantly the overall costs. Furthermore, of 77 GICAT patients treated at the ACC with (group A) or without (group B) long-lasting CR, performance status and the mean CD4+ cell count at time of NHL diagnosis were the only parameters of statistical relevance. Based on our data HIV related NHLs are highly aggressive malignancies which are associated with a poor prognosis per se, and because of the underlying HIV infection. Long-term survivals and possible cures can, nonetheless, be obtained in a subgroup of patients, who have a better performance status and a less advanced immune dysfunction related to HIV infection. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Sinicco, Alessandro
Italy, Turin
Università Degli Studi Di Torino
Rizzardini, Giuliano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Carbone, Antonino
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Serraino, Diego
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Monfardini, Silvio
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Foà, Roberto
Italy, Turin
Università Degli Studi Di Torino
Statistics
Citations: 29
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.3109/10428199509054758
ISSN:
10428194
Research Areas
Cancer
Health System And Policy
Infectious Diseases