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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana
American Journal of Clinical Nutrition, Volume 87, No. 4, Year 2008
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Description
Background: Micronutrient deficiencies are common during infancy, and optimal approaches for their prevention need to be identified. Objective: The objective was to compare the efficacy and acceptability of Sprinkles (SP), crushable Nutritabs (NT), and fat-based Nutributter (NB; 108 kcal/d), which provide 6, 16, and 19 vitamins and minerals, respectively, when used for home fortification of complementary foods. Design: Ghanaian infants were randomly assigned to receive SP (n = 105), NT (n = 105), or NB (n = 103) daily from 6 to 12 mo of age. We assessed dietary intake, morbidity, and compliance weekly. Hemoglobin and plasma ferritin, TfR, C-reactive protein, and zinc were measured at 6 and 12 mo. We used an exit interview to assess acceptability. A randomly selected control group of infants who received no intervention (NI; n = 96) were assessed at 12 mo. Results: All supplements were well accepted, and the mean percentage of days that supplements were consumed (87%) did not differ between groups. At 12 mo, all 3 intervention groups had significantly higher ferritin and lower TfR concentrations than did the NI control group. Mean (± SD) hemoglobin was significantly higher in NT (112 ± 14 g/L) and NB (114 ± 14 g/L) but not in SP (110 ± 14 g/L) infants than in NI infants (106 ± 14 g/L). The prevalence of iron deficiency anemia was 31% in the NI control group compared with 10% in the intervention groups combined (P < 0.0001). Conclusion: All 3 options for home fortification of complementary foods are effective for reducing the prevalence of iron deficiency in such populations. © 2008 American Society for Nutrition.
Authors & Co-Authors
Adu-Afarwuah, Seth
United States, Davis
University of California, Davis
Lartey, Anna A.
Ghana, Accra
University of Ghana
Brown, Kenneth H.
United States, Davis
University of California, Davis
Zlotkin, Stanley Howard
Canada, Toronto
Hospital for Sick Children University of Toronto
Briend, André
France, Marseille
Ird Institut de Recherche Pour le Developpement
Dewey, Kathryn G.
United States, Davis
University of California, Davis
Statistics
Citations: 219
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1093/ajcn/87.4.929
ISSN:
00029165
Research Areas
Food Security
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Ghana