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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
Nature Immunology, Volume 21, No. 11, Year 2020
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Description
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide–MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Peng, Yanchun
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Mentzer, Alexander J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Dejnirattisai, Wanwisa
United Kingdom, Oxford
University of Oxford
Rostron, Tim
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Supasa, Piyada
United Kingdom, Oxford
University of Oxford
Liu, Chang
United Kingdom, Oxford
University of Oxford
López-Camacho, César
United Kingdom, Oxford
University of Oxford
Slon-Campos, José Luis
United Kingdom, Oxford
University of Oxford
Zhao, Yuguang
United Kingdom, Oxford
University of Oxford
Stuart, David Ian
United Kingdom, Oxford
University of Oxford
United Kingdom, Didcot
Diamond Light Source
Paesen, Guido C.
United Kingdom, Oxford
University of Oxford
Grimes, Jonathan M.
United Kingdom, Oxford
University of Oxford
United Kingdom, Didcot
Diamond Light Source
Wang, Beibei
United Kingdom, Oxford
University of Oxford
Turtle, Lance C.W.
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
United Kingdom, Liverpool
University of Liverpool
Subramaniam, Krishanthi S.
United Kingdom, Liverpool
University of Liverpool
Dold, Christina
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Simmonds, Peter N.
United Kingdom, Oxford
University of Oxford
de Silva, Thushan I.
United Kingdom, Sheffield
The University of Sheffield
Sopp, Paul
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Rajapaksa, Ushani S.
United Kingdom, Oxford
University of Oxford
Salio, Mariolina
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Napolitani, Giorgio
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Borrow, Persephone
United Kingdom, Oxford
University of Oxford
Kessler, Benedikt M.
United Kingdom, Oxford
University of Oxford
Semple, Malcolm Gracie
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Hospital
Baillie, J. Kenneth
United Kingdom, Edinburgh
The University of Edinburgh
Moore, Shona C.
United Kingdom, Liverpool
University of Liverpool
Openshaw, Peter J.M.
United Kingdom, London
Imperial College London
Ansari, M. Azim
United Kingdom, Oxford
University of Oxford
Dunachie, Susanna J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Barnes, Eleanor J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Frater, John
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Ho, Ling Pei
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dong, Tao
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Ogg, Graham Stuart
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Kenneth Baillie, J.
United Kingdom, Edinburgh
The University of Edinburgh
Cornall, Richard J.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Conlon, Christopher P.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Screaton, Gavin Robert
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Mongkolsapaya, Juthathip
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Thailand, Nakhon Pathom
Mahidol University
Knight, Julian C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Statistics
Citations: 768
Authors: 44
Affiliations: 16
Identifiers
Doi:
10.1038/s41590-020-0782-6
ISSN:
15292908
Research Areas
Covid