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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population structure of Staphylococcus aureus from remote African Babongo Pygmies
PLoS Neglected Tropical Diseases, Volume 5, No. 5, Article e1150, Year 2011
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Description
Background: Pandemic community-acquired methicillin-resistant Staphylococcus aureus isolates (CA-MRSA) predominantly encode the Panton-Valentine leukocidin (PVL), which can be associated with severe infections. Reports from non-indigenous Sub-Saharan African populations revealed a high prevalence of PVL-positive isolates. The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive. Methodology/Principal Findings: Nasal S. aureus carriage and risk factors of colonization were systematically assessed in remote Gabonese Babongo Pygmies. Susceptibility to antibiotics, possession of toxin-encoding genes (i.e., PVL, enterotoxins, and exfoliative toxins), S. aureus protein A (spa) types and multi-locus sequence types (MLST) were determined for each isolate. The carriage rate was 33%. No MRSA was detected, 61.8% of the isolates were susceptible to penicillin. Genes encoding PVL (55.9%), enterotoxin B (20.6%), exfoliative toxin D (11.7%) and the epidermal cell differentiation inhibitor B (11.7%) were highly prevalent. Thirteen spa types were detected and were associated with 10 STs predominated by ST15, ST30, ST72, ST80, and ST88. Conclusions: The high prevalence of PVL-positive isolates among Babongo Pygmies demands our attention as PVL can be associated with necrotinzing infection and may increase the risk of severe infections in remote Pygmy populations. Many S. aureus isolates from Babongo Pygmies and pandemic CA-MRSA-clones have a common genetic background. Surveillance is needed to control the development of resistance to antibiotic drugs and to assess the impact of the high prevalence of PVL in indigenous populations. © 2011 Schaumburg et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3091839/bin/pntd.0001150.s001.doc
Authors & Co-Authors
Schaumburg, Frieder
Germany, Munster
University of Münster
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Koc̈k, Robin
Germany, Munster
University of Münster
Friedrich, Alexander W.
Germany, Munster
University of Münster
Soulanoudjingar, Solange Solmeheim
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ateba-Ngoa, Ulysse
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Von Eiff, Christof
Germany, Munster
University of Münster
United States, New York
Pfizer Inc.
Issifou, Saadou
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Herrmann, Mathias
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Peters, Georg
Germany, Munster
University of Münster
Becker, Karsten
Germany, Munster
University of Münster
Statistics
Citations: 69
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pntd.0001150
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study