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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A latent trajectory analysis of young sexual and gender minorities’ adherence to three rectal microbicide placebo formulations (MTN-035; a randomized crossover trial)
BMC Public Health, Volume 23, No. 1, Article 2464, Year 2023
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Description
Background: Rectal microbicides (RM) are biomedical HIV prevention products that aim to prevent or reduce the transmission of HIV and other sexually transmitted infections (STIs). RM modalities may be beneficial for populations who have complex lifestyles, difficulties adhering to pre-exposure prophylaxis (PrEP) regimens, and/or have limited access to care. MTN-035 (DESIRE; Developing and Evaluating Short-Acting Innovations for Rectal Use), a randomized crossover trial, aimed to evaluate the safety and acceptability of, and adherence to, three placebo RM modalities (douche, insert, and suppository) prior to receptive anal intercourse. Methods: We conducted latent trajectory analysis to identify clusters of individuals who shared similar trajectories in acceptability and adherence for each product (douche, insert, and suppository) over time. We analyzed weekly short messaging service (SMS) use reports for each modality as reported by enrolled sexual and gender minority (SGM) participants. Results: Two trajectories for each product were identified: a “protocol compliant” trajectory (i.e., at least one product use occasion per week) and “high use” trajectory (i.e., more than three product use occasions per week). Participants with high use were more likely to lack access to PrEP and have higher intentions to utilize RM modalities compared to those who were protocol compliant. Conclusions: This study highlighted high adherence to RM modalities among SGM. As research into viable HIV prevention modalities continues to evolve, tailored intervention strategies are needed to support the uptake of and adherence to alternative prevention modalities that are behaviorally congruent with targeted users. Trial registration: NCT03671239 (14/09/2018). © 2023, The Author(s).
Authors & Co-Authors
Bauermeister, José A.
United States, Philadelphia
University of Pennsylvania
Tingler, Ryan C.
United States, Philadelphia
University of Pennsylvania
Johnson, Sherri
United States, Durham
Fhi 360
Macagna, Nicole
United States, Durham
Fhi 360
Ho, Kenneth S.
United States, Pittsburgh
Magee-womens Research Institute
United States, Pittsburgh
University of Pittsburgh
Hoesley, Craig J.
United States, Birmingham
The University of Alabama at Birmingham
Liu, Albert Y.
United States, San Francisco
San Francisco Department of Public Health
Kayange, Noel
United States, Baltimore
Johns Hopkins University
Palanee-Phillips, Thesla
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
United States, Seattle
University of Washington
Chariyalertsak, Suwat
Thailand, Chaing Mai
Chiang Mai University
Gonzales, Pedro
Peru, San Miguel
Impacta
Piper, Jeanna M.
United States, Bethesda
National Institutes of Health Nih
Statistics
Authors: 12
Affiliations: 12
Identifiers
Doi:
10.1186/s12889-023-17368-y
ISSN:
14712458
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial