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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nasopharyngeal carriage of streptococcus pneumoniae in gambian children who participated in a 9-valent pneumococcal conjugate vaccine trial and in their younger siblings
Pediatric Infectious Disease Journal, Volume 28, No. 11, Year 2009
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Description
BACKGROUND:: Nasopharyngeal carriage of Streptococcus pneumoniae is extremely prevalent in The Gambia. We studied the effects of vaccination with pneumococcal conjugate vaccines on the carriage of individual serotypes and on antimicrobial resistance in vaccinated children and their younger siblings. METHODS:: A longitudinal study of a subsample of children (n = 2342) who participated in a randomized, placebo controlled trial of a 9-valent pneumococcal conjugate vaccines (PCV-9) in The Gambia, and a cross-sectional study of non-PCV-9-vaccinated younger siblings (n = 675). RESULTS:: Recipients of PCV-9 were less likely to carry vaccine serotypes 4, 6B, 9V, 14, 19F, and 23F but more likely to carry vaccine-associated 19A and 9 nonvaccine serotypes at approximately 6 months postvaccination (age, 12 months) than were controls (each P < 0.05). At approximately 16 months postvaccination, carriage of vaccine-associated-serotype 6A was also significantly reduced (P < 0.01) while 3 other nonvaccine serotypes were more prevalent in the PCV-9 recipients (each P < 0.05). At 16 months, but not 6 months, postvaccination PCV-9 recipients had lower rate of carrying isolates resistant to tetracycline and trimethoprim-sulfamethoxazole (TMP-SMZ) than controls (risk ratio: 0.90 and 0.95, respectively; each P < 0.05). There was no difference in patterns of carriage of pneumococci in younger siblings of PCV-9 or placebo recipients. CONCLUSIONS:: The effects of 9-valent pneumococcal conjugate vaccines on carriage of pneumococci persisted for at least 16 months postvaccination in Gambian children. Vaccination had no indirect effect on carriage in younger siblings and there was limited impact on antibiotic resistance. Copyright © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Cheung, Yin Bun
Unknown Affiliation
Zaman, Syed M.A.
Unknown Affiliation
Nsekpong, Ekpedeme D.
Unknown Affiliation
van Beneden, Chris A.
Unknown Affiliation
Adegbola, Richard A.
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Cutts, Felicity T.
Unknown Affiliation
Statistics
Citations: 88
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1097/INF.0b013e3181a78185
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia