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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
veterinary
Chronic enteropathies in dogs: Evaluation of risk factors for negative outcome
Journal of Veterinary Internal Medicine, Volume 21, No. 4, Year 2007
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Description
Hypothesis: Certain variables that are routinely measured during the diagnostic evaluation of dogs with chronic enteropathies will be predictive for outcome and a new clinical disease activity index incorporating these variables can be applied to predict outcome of disease. Animals: Seventy dogs were entered into a sequential treatment trial with elimination diet (FR, food-responsive group) followed by immunosuppressive treatment with steroids if no response was seen with the dietary trial alone (ST, steroid-treatment group). A 3rd group consisted of dogs with panhypoproteinemia and ascites (PLE, protein-losing enteropathy) that were treated with immunosuppressive doses of steroids. Methods: Three years of follow-up information was available for all dogs. Clinicopathologic variables were tested for their ability to predict negative outcome, defined as euthanasia due to refractoriness to treatment. Different scoring systems including different combinations of these variables were evaluated using receiver operating characteristic (ROC) curves. Results: Thirteen of 70 (18%) dogs were euthanized because of intractable disease. Univariate analysis identified a high clinical activity index, high endoscopic score in the duodenum, hypocobalaminemia (<200 ng/L) and hypoalbuminemia (<20 g/L) as risk factors for negative outcome. Conclusions and clinical importance: Based on the factors identified by logistic regression and ROC curve analysis, a new clinical scoring index (CCECAI) was defined that predicts negative outcome in does suffering from chronic enteropathies. Copyright © 2007 by the American College of Veterinary Internal Medicine.
Authors & Co-Authors
Wieland, Barbara
United Kingdom, London
Royal Veterinary College University of London
Gaschen, Frédéric P.
Switzerland, Bern
University of Bern
United States, Baton Rouge
Louisiana State University
Statistics
Citations: 472
Authors: 2
Affiliations: 4
Identifiers
Doi:
10.1892/0891-6640(2007)21[700:CEIDEO]2.0.CO;2
ISSN:
08916640
Research Areas
Food Security
Health System And Policy
Study Design
Cohort Study