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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Aggressive Fluid Resuscitation and Broad Spectrum Antibiotics Decrease Mortality from Typhoid Ileal Perforation
Tropical Doctor, Volume 25, No. 3, Year 1995
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Description
One of the most severe complications of typhoid enteritis is perforation of ileal ulcerations. The typically high mortality rates from these perforations are in part due to extremely limited supportive care in hospitals in typhoid endemic areas. In the setting of a rural African hospital, this study demonstrated a decrease in overall mortality rate from 40% with one layer closure and chloramphenicol alone to 19% with two-layer closure and chloramphenicol, gentamicin and metronidazole. This was primarily due to a decrease in late (> 24 h) mortality. There was also a decrease in overall mortality rate from 43% with < 10 ml/kg of intraoperative fluid administration to 14% with > 10 ml/kg. This was primarily due to a decrease in early (< 24 h) mortality. Even within the constraints of the rural developing world, more aggressive initial fluid resuscitation can decrease early mortality, while broader spectrum antibiotics and two-layer closure can decrease late mortality from typhoid ileal perforation. © 1995, SAGE Publications. All rights reserved.
Authors & Co-Authors
Visser, Lucia E.
Ghana
Holy Family Hospital
Mock, Charles
United States, Seattle
University of Washington
Maier, Ronald
United States, Seattle
University of Washington
Denno, Donna Marie
United States, Seattle
University of Washington
Statistics
Citations: 21
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1177/004947559502500309
ISSN:
00494755
e-ISSN:
17581133
Research Areas
Health System And Policy
Infectious Diseases