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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid
FEMS Microbiology Letters, Volume 259, No. 1, Year 2006
Notification
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Description
Spent culture supernatant (SCS) of the probiotic Lactobacillus rhamnosus GG had been reported to exert antibacterial activity against Salmonella typhimurium. However, the chemical identity of the antimicrobial compound(s) responsible remained unknown. A survey of the antimicrobial compounds produced by L. rhamnosus GG was performed. Lactobacillus rhamnosus GG produced a low-molecular weight, heat-stable, non-proteinaceous bactericidal substance, active at acidic pH against a wide range of bacterial species. SCS of L. rhamnosus GG grown in MRS medium contained five compounds that could meet the above description, if present at the appropriate concentration. Based on different experimental approaches, it could be concluded that under the growth conditions tested, the strong antimicrobial activity of L. rhamnosus GG against Salmonella was mediated by lactic acid. © 2006 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved.
Authors & Co-Authors
De Keersmaecker, Sigrid C.J.
Belgium, Leuven
Ku Leuven
Marchal, Kathleen
Belgium, Leuven
Ku Leuven
Vanderleyden, Jos X.
Belgium, Leuven
Ku Leuven
Nágy, István
Belgium, Leuven
Ku Leuven
Germany, Planegg
Max-planck-institut Für Biochemie
Statistics
Citations: 247
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1574-6968.2006.00250.x
ISSN:
15746968
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative