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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ischemic Stroke With Cerebral Protection System During Transcatheter Aortic Valve Replacement
JACC: Cardiovascular Interventions, Volume 13, No. 18, Year 2020
Notification
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Description
Objectives: The objective of this study was to evaluate in-hospital outcomes with use of the Sentinel cerebral protection system (CPS) in transcatheter aortic valve replacement (TAVR). Background: The role of the Sentinel CPS in preventing clinical ischemic stroke has been controversial. Methods: The Nationwide Inpatient Sample database from the last three quarters of 2017, after the approval of the Sentinel CPS device, was queried to identify hospitalizations for TAVR. A 1:2 propensity score–matched analysis to compare in-hospital outcomes with versus without use of the CPS. The primary outcome was the occurrence of ischemic strokes. Results: A total of 36,220 weighted discharges of patients who underwent TAVR (525 with the CPS and 35,695 without) were identified. The overall percentages of ischemic and hemorrhagic strokes were 2.4% and 0.2%, respectively. After propensity score matching (525 CPS, 1,050 no CPS), the risk for ischemic stroke was lower with use of the CPS (1 % vs. 3.8%, odd ratio [OR]: 0.243 (95% confidence interval: 0.095 to 0.619); p = 0.003). The cost of the index hospitalization was higher with use of the CPS ($47,783 vs. $44,578; p = 0.002). In multivariate regression analysis, use of the CPS was independently associated with a lower risk for ischemic stroke (OR: 0.380; 95% confidence interval: 0.157 to 0.992; p = 0.032). Conclusions: Use of the Sentinel CPS in patients undergoing TAVR is associated with a lower incidence of ischemic stroke and in-hospital mortality, without an increased risk for procedural complications but with an increased cost of the index hospitalization. © 2020 American College of Cardiology Foundation
Authors & Co-Authors
Megaly, Michael S.
United States, Minneapolis
Abbott Northwestern Hospital
United States, Minneapolis
Cardiovascular Division
Sorajja, Paul
United States, Minneapolis
Abbott Northwestern Hospital
Cavalcante, Joao L.
United States, Minneapolis
Abbott Northwestern Hospital
Pershad, Ashish
United States, Tucson
The University of Arizona
Gössl, Mario
United States, Minneapolis
Abbott Northwestern Hospital
Abraham, Bishoy
United States, Detroit
St. John Hospital and Medical Center
Omer, Mohamed A.
United States, Minneapolis
Abbott Northwestern Hospital
United States, Minneapolis
Cardiovascular Division
Elbadawi, Ayman
United States, Galveston
The University of Texas Medical Branch at Galveston
García, Santiago Andrés
United States, Minneapolis
Abbott Northwestern Hospital
Statistics
Citations: 34
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.jcin.2020.05.039
ISSN:
19368798
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative