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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution
Environmental Research, Volume 109, No. 8, Year 2009
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Description
Exposure to traffic-related air pollution in urban environment is common and has been associated with adverse human health effects. In utero exposures that result in DNA damage may affect health later in life. Early effects of maternal and in utero exposures to traffic-related air pollution were assessed through the use of validated biomarkers in blood cells from mother-newborn pairs. A cross-sectional biomonitoring study with healthy pregnant women living in the Greater Copenhagen area, Denmark, was conducted. Bulky DNA adducts and micronuclei (MN) were measured in blood from 75 women and 69 umbilical cords, concurrently collected at the time of planned Caesarean section. Modeled residential traffic density, a proxy measure of traffic-related air pollution exposures, was validated by indoor levels of nitrogen dioxide and polycyclic aromatic hydrocarbons in 42 non-smoking homes. DNA adduct levels were similar and positively correlated in maternal and cord blood (1.40 vs. 1.37 n/108 nucleotides; r=0.99; p<0.01). Maternal MN frequencies were significantly associated with age (p<0.01), and higher than those of the newborns (7.0 vs. 3.2 MN per 1000 binucleated cells). Adduct levels were highest among mother-newborn pairs who lived near medium-traffic-density (>400-2500 vehicle km/24 h; p<0.01) places. MN frequencies among newborns from women who lived at high-traffic-density homes (>2500 vehicle km/24 h) were significantly increased (p=0.02). This trend remained after adjusting for potential confounders and effect modifiers. For the first time increased bulky DNA adducts and MN in cord blood after maternal exposures to traffic-related air pollution are found, demonstrating that these transplacental environmental exposures induce DNA damage in newborns. Given that increased DNA damage early in life indicate an increased risk for adverse health effects later in life, these findings justify intervention of pregnant women. © 2009 Elsevier Inc. Allrightsreserved.
Authors & Co-Authors
Wichmann, Janine
Denmark, Copenhagen
Københavns Universitet
Autrup, Herman N.
Denmark, Aarhus
Aarhus Universitet
Loft, Steffen H.
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 98
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.envres.2009.08.011
ISSN:
00139351
Research Areas
Environmental
Genetics And Genomics
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Participants Gender
Female