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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term outcomes after multidisciplinary management of T3 laryngeal squamous cell carcinomas: Improved functional outcomes and survival with modern therapeutic approaches
Head and Neck, Volume 38, No. 12, Year 2016
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Description
Background: The purpose of this study was to evaluate the long-term outcomes after initial definitive or adjuvant radiotherapy (RT) for T3 laryngeal cancers. Methods: We reviewed 412 patients treated for T3 laryngeal squamous cell cancer from 1985 to 2011. Results: The 10-year overall survival (OS) was 35%; disease-specific-survival (DSS) was 61%; locoregional control was 76%; and freedom from distant metastasis was 83%. Chemotherapy, age, performance status <2, node-negative status, and glottic subsite were associated with improved survival (all p <.03). Larynx preservation with induction and/or concurrent chemoradiotherapy (LP-CRT) had better laryngectomy-free survival than RT alone (LP-RT; hazard ratio [HR] = 0.62; 95% confidence interval [CI] = 0.47–0.81; p =.0005); 10-year laryngectomy-free survival rates of the LP-CRT cohort (37%) were higher than those of the LP-RT cohort (18%). The 5-year DSS and OS rates of the LP-CRT cohort (79% and 67%) were better after total laryngectomy with postoperative RT (TL-PORT; 61% and 50%) and LP-RT (64% and 46%; p <.006 for all). Conclusion: In patients with T3 laryngeal cancers, LP-CRT provides better functional, oncologic, and survival outcomes than historical TL-PORT or LP-RT does. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1739–1751, 2016.
Authors & Co-Authors
Fuller, Clifton David
United States, Houston
The University of Texas Md Anderson Cancer Center
Mohamed, Abdallah Sherif Radwan
United States, Houston
The University of Texas Md Anderson Cancer Center
Egypt, Alexandria
Faculty of Medicine
Garden, Adam Seth
United States, Houston
The University of Texas Md Anderson Cancer Center
Gunn, G. Brandon
United States, Houston
The University of Texas Md Anderson Cancer Center
Mulcahy, Collin
United States, Houston
The University of Texas Md Anderson Cancer Center
Zafereo, Mark Edwin
United States, Houston
The University of Texas Md Anderson Cancer Center
Phan, Jack
United States, Houston
The University of Texas Md Anderson Cancer Center
Lai, Stephen Y.
United States, Houston
The University of Texas Md Anderson Cancer Center
Lewin, Jan S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Hutcheson, Katherine A.
United States, Houston
The University of Texas Md Anderson Cancer Center
Frank, Steven J.
United States, Houston
The University of Texas Md Anderson Cancer Center
Beadle, Beth M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Morrison, William H.
United States, Houston
The University of Texas Md Anderson Cancer Center
El-Naggar, Adel K.H.
United States, Houston
The University of Texas Md Anderson Cancer Center
Kocak–Uzel, Esengul
United States, Houston
The University of Texas Md Anderson Cancer Center
Turkey, Istanbul
Sisli Etfal Hospital
Ginsberg, Lawrence E.
United States, Houston
The University of Texas Md Anderson Cancer Center
Kies, Merrill S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Weber, Randal S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Rosenthal, David I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Statistics
Citations: 32
Authors: 19
Affiliations: 3
Identifiers
Doi:
10.1002/hed.24532
ISSN:
10433074
e-ISSN:
10970347
Research Areas
Cancer
Environmental
Study Design
Cohort Study