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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
L-arginine efficiency in MELAS syndrome. A case report
Revue Neurologique, Volume 165, No. 5, Year 2009
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Description
Introduction. Mitochondrial encephalomyopathy lactic acidosis and stoke-like episodes (MELAS) is a rare neurodegenerative disease caused by mutations of mitochondrial DNA.Case report. We report the case of a 12-year-old child with MELAS syndrome who presented with recurrent migraine-like headache and sudden blindness suggesting stroke-like episodes. Furthermore, he developed progressive muscular impairment with bilateral hearing loss. Serum lactate and pyruvate levels were elevated and the muscle biopsy showed an aspect of red-ragged fibers with Gomori trichrome. Brain imaging showed calcifications of basal ganglia on the CT scan and a parieto-occipital high signal on diffusionweighted MRI. A genetic analysis was not performed but the presence of hearing loss in the patients mother was suggestive of maternal transmission. Stroke-like episodes in the form of migraine-like headache and blindness were the patients major complaint and did not improve despite analgesic drugs. After oral administration of L-arginine at the dose of 0.4 mg/kg per day, stroke-like symptoms totally and rapidly disappeared. Discussion. The efficiency of L-arginine in stroke-like episodes was initially reported then confirmed in a controlled study. The pathophysiology of stoke-like episodes and the mechanisms underlying the action of L-arginine are discussed. © 2008 Elsevier Masson SAS.
Authors & Co-Authors
Moutaouakil, Fettouma
Morocco, Tanger
Hôpital al Kortobi
El Otmani, Hicham
Morocco, Tanger
Hôpital al Kortobi
Fadel, Hicham
Morocco, Tanger
Hôpital al Kortobi
Sefrioui, F.
Morocco, Tanger
Radiologie al Hakim
Slassi, Ilham
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Statistics
Citations: 9
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.neurol.2008.08.006
ISSN:
00353787
Research Areas
Disability
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases