Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults
PLoS ONE, Volume 8, No. 5, Article e58390, Year 2013
Notification
URL copied to clipboard!
Description
Rationale:Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.Objectives:This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.Methods:Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.Measurements and Main Results:In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.Conclusions:After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function. © 2013 McEvoy et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3655195/bin/pone.0058390.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3655195/bin/pone.0058390.s002.docx
Authors & Co-Authors
McEvoy, Mark A.
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Agho, Kingsley Emwinyore
Australia, Penrith
Western Sydney University
Zinellu, Angelo
Italy, Sassari
Università Degli Studi Di Sassari
Attia, John Richard
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Australia, Newcastle
John Hunter Hospital
Statistics
Citations: 11
Authors: 4
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0058390
ISSN:
19326203
Study Design
Cross Sectional Study